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merck millipore,默克密理博,AB16661,Anti-PARP Poly ADP-ribose Polymerase-1 Antibody
产品名称：Anti-PARP Poly ADP-ribose Polymerase-1 Antibody
产品型号：AB16661
This Anti-PARP Poly ADP-ribose Polymerase-1 Antibody is validated for use in ELISA, WB for the detection of PARP Poly ADP-ribose Polymerase-1.
merck millipore,默克密理博,AB16661,Anti-PARP Poly ADP-ribose Polymerase-1 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, B, H, M WB, ELISA Rb Serum Polyclonal Antibody 描述 产品目录编号 AB16661 Replaces 04-575; 04-576 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-PARP Poly ADP-ribose Polymerase-1 Antibody Alternate Names - ARTD1
- Poly [ADP-ribose] polymerase 1
- PARP-1
- NAD(+) ADP-ribosyltransferase 1
- ADPRT 1
- Poly[ADP-ribose] synthase 1
产品信息 格式 Serum 演示 Antiserum containing 0.05% sodium azide. Liquid containing 0.05% sodium azide. 应用 应用 This Anti-PARP Poly ADP-ribose Polymerase-1 Antibody is validated for use in ELISA, WB for the detection of PARP Poly ADP-ribose Polymerase-1. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1:500 using alkaline phosphatase.
ELISA
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide based on the sequence from the C-terminal portion of the bovine PARP automodification domain (amino acids 509-524) conjugated to a carrier. 宿主 Rabbit 特异性 Recognizes 116 kDa PARP-1 and the 85 kDa apoptosis-related cleavage fragment. 品种反应性 RatBovineHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001618.3
Entrez基因汇总 This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. 基因符号 - pADPRT-1
- PARP-1
- ADPRT1
- Poly
- PARP
- ADPRT
- PPOL
- NAD
- EC 2.4.2.30
- PARP1
- poly(ADP-ribosyl)transferase
UniProt编号 - P09874
UniProt汇总 FUNCTION: SwissProt: P09874 # Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
SIZE: 1014 amino acids; 113084 Da
SUBUNIT: Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with ZNF423 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR. & Poly-ADP-ribosylated by PARP2.
SIMILARITY: SwissProt: P09874 ## Contains 1 BRCT domain. & Contains 1 PARP alpha-helical domain. & Contains 1 PARP catalytic domain. & Contains 2 PARP-type zinc fingers.
MISCELLANEOUS: The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µL
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