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经验配方 CAS号 C₂₁H₂₇N₇O 656820-32-5 描述 概述 A cell-permeable, 2,6-disubstituted purine analog that acts as a dedifferentiation-inducing agent. Shown to induce mouse C2C12 myoblast cells to become multipotent mesenchymal progenitor cells in the concentration range of 1-10 µM. The first organic molecule that has been demonstrated to reverse the cellular differentiation process. Acts as a selective A3 adenosine receptor antagonist (Ki = 660 nM, >10 µM, and >10 µM for hA3, hA1, and hA2A, respectively. Functions as a dual inhibitor of MEK1 and nonmuscle myosin II heavy chain (IC50 = 8 and 10 nM, respectively). Also acts as an ATP-competitive, reversible and selective inhibitor of Aurora Kinases A, B and C (IC50 = 400, 500 and 400 nM, respectively) in a 26-kinase panel. Shown to be a potent, selective, and ATP-competitive inhibitor of MPS1 (IC50 = 2.8 nM, full-length enzyme). 产品目录编号 554717 品牌系列 Calbiochem®
同义词 2-(4-Morpholinoanilino)-6-cyclohexylaminopurine, Aurora Kinase Inhibitor V, CD45 Inhibitor II, PTP Inhibitor XIII, VHR Inhibitor I, MLCK Inhibitor V 参考 参考 Santaguida, S., et al. 2010. J. Cell Biol. 190, 73.
D'Alise, A.M., et al. 2008. Mol. Cancer Ther. 7, 1140.
Chen, S., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 10482.
Perreira, M., et al. 2005. J. Med. Chem. 48, 4910.
Chen, S., et al. 2004. J. Am. Chem. Soc., 126, 410.产品信息 CAS号 656820-32-5 具有ATP竞争性 Y 形式 Off-white solid Hill配方 C₂₁H₂₇N₇O 化学配方 C₂₁H₂₇N₇O Molar Mass 393.5 可逆 Y 结构配方图像 生物信息 主靶 Dedifferentiation-inducing agent 主靶IC50 8 and 10 nM, against MEK1 and nonmuscle myosin II heavy chain, respectively; 400, 500 and 400 nM, against Aurora Kinases A, B and C, respectively 主靶Ki 660 nM against A3 adenosine receptor 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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