merck millipore,默克密理博,203646,BMP Inhibitor II, DMH1 - CAS 1206711-16-1

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Merck Millipore 默克密理愽

merck millipore,默克密理博,203646,BMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem

经验配方	CAS号
C₂₄H₂₀N₄O	1206711-16-1

描述
概述	A cell-permeable, potent, and highly selective BMPR inhibitior (IC₅₀ against human ALK2/BMPR-I = 107.9 nM), exhibiting no activity toward ALK5, ALK6, AMPK, FLK1/KDR/VEGRF2, or PDGFRβ. Comparing to its non-BMPR-selective structural analog dorsomorphin (Cat. Nos. 171260 & 171261), DMH1 is 12.5-times more potent in preventing BMP pathway-dependent dorsoventral development (EC₁₀₀ = 0.2 µM) in zebrafish embryo in vivo, while being non-toxic to the fish embryo and exhibiting no effect against VEGF signaling-dependent intersomitic vessel formation even at concentrations as high as 50 µM.
产品目录编号	203646
品牌系列	Calbiochem®
同义词	ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

参考
参考	Hao, J., et al. 2010. ACS Chem.Biol. 5, 245.

生物信息
纯度	≥97% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Regulatory Review
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,203646,BMP Inhibitor II, DMH1 - CAS 1206711-16-1 - Calbiochem

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