merck millipore,默克密理博,203734,Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,203734,Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem
产品名称：Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem
产品型号：203734
Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida.

merck millipore,默克密理博,203734,Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem

产品介绍

merck millipore,默克密理博,203734,Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem

重要规格表

经验配方	CAS号
C₅₀H₇₂O₁₄	85079-48-7

描述
概述	Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.
产品目录编号	203734
品牌系列	Calbiochem®
同义词	Pumiliotoxin, Dihydrobrevetoxin B

参考
参考	Baden, D.G., et al. 1994. Nat. Toxins 2, 212. Rein, K., et al. 1994. J. Org. Chem. 59, 2107. Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64. Trainer, V.L. 1991. Mol. Pharmacol. 40, 988. Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126. Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166. Baden, D.G., et al. 1988. Toxicon 26, 97. Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129. Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514. Baden, D.G., et al. 1982. Toxicon 19, 455. Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.

参考

Baden, D.G., et al. 1994. Nat. Toxins 2, 212.
Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
Baden, D.G., et al. 1988. Toxicon 26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
Baden, D.G., et al. 1982. Toxicon 19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.

产品信息
CAS号	85079-48-7
具有ATP竞争性	N
形式	Solid
Hill配方	C₅₀H₇₂O₁₄
化学配方	C₅₀H₇₂O₁₄
Molar Mass	897.1
可逆	N
结构配方图像

生物信息
主靶	Voltage-dependent Na+ channel activator
纯度	>95% by HPLC

理化信息
细胞可渗透	N
溶解度	MeOH or H₂O

GHS安全信息
RTECS	XW5885000

安全信息
R相	R: 26/27/28 Very toxic by inhalation, in contact with skin and if swallowed.
S相	S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Blue Ice Only
毒性	Highly Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use teflon or silicon pipette tips.
最终使用证书	Y