merck millipore,默克密理愽
  • merck millipore,默克密理博,658403,AG 538 - CAS 133550-18-2 - Calbiochem

  • merck millipore,默克密理博,658403,AG 538 - CAS 133550-18-2 - Calbiochem

    产品名称：AG 538 - CAS 133550-18-2 - Calbiochem
    产品型号：658403
    A potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC₅₀ = 400 nM).

    merck millipore,默克密理博,658403,AG 538 - CAS 133550-18-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,658403,AG 538 - CAS 133550-18-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁NO₅133550-18-2
    描述
    概述 A potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC50 = 400 nM). Reaction is competitive with respect to IGF-1R substrate. Also inhibits the phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC50 = 60 nM, 113 nM, 370 nM, and 2.4 µM, respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC50 = 76 µM).
    产品目录编号 658403
    品牌系列 Calbiochem®
    同义词 α-Cyano-(3,4-dihydroxy)cinnamoyl-(3ʹ,4ʹ-dihydroxyphenyl)ketone, Tyrphostin AG 538
    参考
    参考 Blum, G., et al. 2000. Biochemistry 39, 15705.
    产品信息
    CAS号 133550-18-2
    具有ATP竞争性 Y
    形式 Dark yellow solid
    Hill配方 C₁₆H₁NO₅
    化学配方 C₁₆H₁NO₅
    Molar Mass 297.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 IGF-1 receptor kinase
    主靶IC50 400 nM against IGF-1 receptor kinase
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,658403,AG 538 - CAS 133550-18-2 - Calbiochem

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