• merck millipore,默克密理博,181315,ARE Activator, BTZO-1 - Calbiochem
  • merck millipore,默克密理博,181315,ARE Activator, BTZO-1 - Calbiochem

    产品名称:ARE Activator, BTZO-1 - Calbiochem
    产品型号:181315
    The ARE Activator, BTZO-1 modulates the biological activity of ARE. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,181315,ARE Activator, BTZO-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,181315,ARE Activator, BTZO-1 - Calbiochem

    重要规格表

    经验配方
    C₁₃H₈N₂OS
    描述
    概述 A cell-permeable benzothiazinone that is shown to interact with MIF homotrimer (Kd = 68.6 nM and 157 nM toward human and rat MIF, respectively, at pH 7.3) via the N-terminal proline in a pH-dependent manner, limiting its inhibitory capability against MIF tautomerase activity (13% inhibition at pH 6.0; [BTZO-1] = 30 µM) due to reduced MIF binding at acidic pH. Shown to protect primary rat cardiomyocytes (330 nM) from apoptotic death upon serum deprivation or DOX (200 nM; Cat. No. 324380) treatment via activation of ARE- (antioxidant response element) mediated cytoprotective genes transcription in a MIF-dependent manner.
    产品目录编号 181315
    品牌系列 Calbiochem®
    同义词 2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one, Antioxidant Response Element Activator, Macrophage Migration Inhibitory Factor Antagonist II, MIF Antagonist II
    参考
    参考 Kimura, H., et al. 2010. Chem. Biol. 17, 1282.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₃H₈N₂OS
    化学配方 C₁₃H₈N₂OS
    Molar Mass 240.3
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freez e(-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,181315,ARE Activator, BTZO-1 - Calbiochem

上一件merck millipore产品:merck millipore,默克密理博,MABT171,Anti-MMP-9 (Active) Antibody, clone 4A3
下一件merck millipore产品:merck millipore,默克密理博,14-805M,Met (Y1248C) Protein, active, 250 µg



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