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merck millipore,默克密理博,181315,ARE Activator, BTZO-1 - Calbiochem
产品名称:ARE Activator, BTZO-1 - Calbiochem
产品型号:181315
The ARE Activator, BTZO-1 modulates the biological activity of ARE. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,181315,ARE Activator, BTZO-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₃H₈N₂OS 描述 概述 A cell-permeable benzothiazinone that is shown to interact with MIF homotrimer (Kd = 68.6 nM and 157 nM toward human and rat MIF, respectively, at pH 7.3) via the N-terminal proline in a pH-dependent manner, limiting its inhibitory capability against MIF tautomerase activity (13% inhibition at pH 6.0; [BTZO-1] = 30 µM) due to reduced MIF binding at acidic pH. Shown to protect primary rat cardiomyocytes (330 nM) from apoptotic death upon serum deprivation or DOX (200 nM; Cat. No. 324380) treatment via activation of ARE- (antioxidant response element) mediated cytoprotective genes transcription in a MIF-dependent manner. 产品目录编号 181315 品牌系列 Calbiochem®
同义词 2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one, Antioxidant Response Element Activator, Macrophage Migration Inhibitory Factor Antagonist II, MIF Antagonist II 参考 参考 Kimura, H., et al. 2010. Chem. Biol. 17, 1282. 产品信息 形式 Off-white solid Hill配方 C₁₃H₈N₂OS 化学配方 C₁₃H₈N₂OS Molar Mass 240.3 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freez e(-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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