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品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, M, R WB Rb Serum Polyclonal Antibody 描述 产品目录编号 06-222 品牌系列 Upstate
商名 - Upstate
描述 Anti-PP2A Antibody, C subunit 产品信息 格式 Serum 控制 - Positive Control Included: Non-Stim A431 Cell Lysate (12-301). Other controls: HeLa whole cel lysate, mouse NIH3T3 cells
演示 Immunoaffinity Purified immunoglobulin in 150mM Tris, pH 7.4, 0.02% sodium azide, 50% glycerol and 5mg/ml BSA 应用 应用 Anti-PP2A Antibody, C subunit is an antibody against PP2A for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to the C-terminal amino acid residues 296-309 of human protein phosphatase 2A 宿主 Rabbit 特异性 Recognizes PP2A-subunit alpha and PP2A-subunit beta; does not react with PP1 or other protein phosphatases. 同种型 IgG 品种反应性 RabbitHumanMouseRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002706
- NM_002715.2
Entrez基因汇总 The protein encoded by this gene is the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. 基因符号 - PP2Ac
- PPP2CA
- PP2CA
- PP2A-alpha
- RP-C
纯化方法 Unpurified UniProt编号 - P62714
- P67775
UniProt汇总 FUNCTION: SwissProt: P67775 # PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen.
COFACTOR: Binds 1 iron ion per subunit; Binds 1 manganese ion per subunit
SIZE: 309 amino acids; 35594 Da
SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct.
SUBCELLULAR LOCATION:Cytoplasm.
SIMILARITY: SwissProt: P67775 ## Belongs to the PPP phosphatase family. PP-1 subfamily.产品使用声明 质量保证 routinely evaluated by immunoblot on a rabbit brain cytosol or in a human A431 RIPA cell lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 200 µg
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