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merck millipore,默克密理博,16-235,Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor 488
产品名称：Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor 488
产品型号：16-235
This Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor 488 is validated for use in FC, IC for the detection of phospho-erbB-2/HER-2 (Tyr1248).
merck millipore,默克密理博,16-235,Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor 488
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H ICC, FC Rb AlexaFluor®488 Polyclonal Antibody 描述 产品目录编号 16-235 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor® 488 产品信息 格式 AlexaFluor®488 应用 应用 This Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor 488 is validated for use in FC, IC for the detection of phospho-erbB-2/HER-2 (Tyr1248). 主要应用 - Immunocytochemistry
- Flow Cytometry
生物信息 免疫原品种 Synthetic phosphopeptide, residues 1243-1255, corresponding to a major autophosphorylation (Tyr1248) site of human Erb B2/HER-2 (C-AENPEpYLGLDVPV) 宿主 Rabbit 特异性 the activated form of Erb B2/HER-2 oncoprotein 同种型 IgG 品种反应性 RatHuman Species Reactivity Note Predicted to cross react with rat based on conservation of immunogenic sequence 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004448.2
- NM_001005862.1
Entrez基因汇总 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. 基因符号 - HER-2/neu
- ERBB2
- HER2
- HER-2
- NGL
- herstatin
- erbB-2
- C-erbB-2
- NEU
- TKR1
- p185erbB2
修改 - Phosphorylation
纯化方法 Immunoaffinity purified UniProt编号 - P04626
UniProt汇总 FUNCTION: SwissProt: P04626 # Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF- alpha and amphiregulin.
SIZE: 1255 amino acids; 137910 Da
SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Ligand-binding increases phosphorylation on tyrosine residues (By similarity).
SIMILARITY: SwissProt: P04626 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by immunostaining of EGF treated A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
储存和货运信息 存储条件 1 year at 4°C from date of shipment 包装信息 数量 100 µg
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