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品种反应性 主要应用 宿主 格式 抗体类型 R WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5246-200UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-P2X7 Receptor Antibody 产品信息 格式 Affinity Purified 控制 - CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile distilled water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). 应用 应用 Anti-P2X7 Receptor Antibody detects level of P2X7 Receptor & has been published & validated for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western blot:1:200-1:1000 using ECL on rat brain membranes.
Immunohistochemistry (Vial & Evans 2000; Lewis & Evans 2000; Gitterman & Evans 2000)
Dilutions should be made using a carrier protein such as BSA (1-3%)
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified peptide P2X7 from 576-595 of rat P2X7 (Koshlukova et al. 2000). 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 The epitope is specific for P2X7 and is not present in any other known protein.
SPECIES REACTIVITIES: Rat, mouse (Solee et al. 2001) and Candida albicans (Koshlukova et al. 2000). The sequence is highly conserved in mouse and human (18/20 and 16/20 residues identical, respectively). Reactivity with other species has not been tested.品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002562.4
Entrez基因汇总 The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. 基因符号 - P2X7
- P2RX7
- MGC20089
UniProt编号 - Q99572
UniProt汇总 FUNCTION: SwissProt: Q99572 # Receptor for ATP that acts as a ligand gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
SIZE: 595 amino acids; 68559 Da
SUBUNIT: Forms homo- or heteropolymers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
PTM: Phosphorylation results in its inactivation.
SIMILARITY: SwissProt: Q99572 ## Belongs to the P2X receptor family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 200 µL
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