merck millipore,默克密理愽
  • merck millipore,默克密理博,506170,p53-Snail binding Inhibitor, GN25 - Calbiochem

  • merck millipore,默克密理博,506170,p53-Snail binding Inhibitor, GN25 - Calbiochem

    产品名称：p53-Snail binding Inhibitor, GN25 - Calbiochem
    产品型号：506170
    The p53-Snail binding Inhibitor, GN25 controls the biological activity of p53-Snail. This small molecule/inhibitor is primarily used for Neuroscience applications.

    merck millipore,默克密理博,506170,p53-Snail binding Inhibitor, GN25 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,506170,p53-Snail binding Inhibitor, GN25 - Calbiochem

    重要规格表

    经验配方
    C₁₅H₁₄O₆S
    描述
    概述 A cell-permeable, water soluble and specific p53-Snail binding inhibitor that activates p53 in a K-Ras-dependent manner and displays anti-proliferating effect toward K-Ras-MEF (K-Ras-transformed mouse embryonic fibroblast) cells with 20% viability at 10µM, but not in N-Ras/Myc-MEF or non-transformed MEF. Snail and p53 expression are elevated in a dose dependent manner after GN25 treatment at 1-10µM in K-Ras-mutated human cancer cell lines A549, but not in MKN-45 (wt-K-Ras/wt-p53) cells. Furthermore, it is shown to selectively activate wild-type p53 in p53WT/MT cancer cells, but not Panc-1 cells with single allelic mutant p53. Exhibits anti-tumor effect in a xenograft model in vivo.
    产品目录编号 506170
    品牌系列 Calbiochem®
    同义词 GN25
    参考
    参考 Lee, S., et al. 2010. Oncogene 29, 4576.
    产品信息
    形式 Orange powder
    Hill配方 C₁₅H₁₄O₆S
    化学配方 C₁₅H₁₄O₆S
    Molar Mass 322.33
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,506170,p53-Snail binding Inhibitor, GN25 - Calbiochem

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