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描述 产品目录编号 12-367 品牌系列 Upstate
商名 - Upstate
描述 ATF2 (aa 19-96) 产品信息 演示 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij-35, 1mM benzamidine, 0.2mM PMSF and 50% glycerol 应用 应用 ATF2 (aa 19-96) primarily used in Kinase Assays. 主要应用 - Kinase Assay
生物信息 品种 Human Entrez基因编号 - NM_001880.2
Entrez基因汇总 This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined. 基因符号 - HB16
- ATF2
- MGC111558
- CREB2
- TREB7
- CRE-BP1
- CREBP1
UniProt编号 - P15336
UniProt汇总 FUNCTION: SwissProt: P15336 # Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.
SIZE: 487 amino acids; 52277 Da
SUBUNIT: Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Abundant expression seen in the brain.
PTM: Phosphorylation of Thr-51 and Thr-53 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK.
SIMILARITY: SwissProt: P15336 ## Belongs to the bZIP family. ATF subfamily. & Contains 1 bZIP domain. & Contains 1 C2H2-type zinc finger.产品使用声明 质量保证 Routinely evaluated by phosphorylation by JNK1α1/SAPK1c, active (Catalog #14-327). 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -20°C 包装信息 数量 1 mg
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