merck millipore,默克密理博,330175,Echinomycin Streptomyces sp. - CAS 512-64-1

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merck millipore,默克密理博,330175,Echinomycin Streptomyces sp. - CAS 512-64-1 - Calbiochem
产品名称：Echinomycin Streptomyces sp. - CAS 512-64-1 - Calbiochem
产品型号：330175
A cell-permeable Streptomyces-derived antibiotic that contains two bicyclic peptide-linked quinoxalines and acts as a sequence-specific DNA bisintercalator.

merck millipore,默克密理博,330175,Echinomycin Streptomyces sp. - CAS 512-64-1 - Calbiochem

产品介绍

merck millipore,默克密理博,330175,Echinomycin Streptomyces sp. - CAS 512-64-1 - Calbiochem

重要规格表

经验配方	CAS号
C₅₁H₆₄N₁₂O₁₂S₂	512-64-1

描述
概述	A cell-permeable Streptomyces-derived antibiotic that contains two bicyclic peptide-linked quinoxalines and acts as a sequence-specific DNA bisintercalator. Echinomycin at 10 µM is shown to inhibit HIF-1 and Myc/Max DNA binding activities in U251 and MCF-7 nuclear extracts by >90%, while exhibiting little effect against the binding of AP-1 or NF-κB to their respective DNA targets that lack the 5'-ACGTG-3' core structure in cell-free EMSA assays. Reversibly inhibits hypoxia-induced HIF-1 transcription activity in an HRE promoter-based reporter assay in U215 cells (EC₅₀ = 1.2 nM) and is of no effect against SV40 promoter-driven transcription activity. Despite echinomycin's in vitro apoptosis-inducing activity and the initial report of its in vivo antitumor effect in mice, clinical trials have not yet resulted in promising data regarding its therapeutic efficacy in cancer treatment.
产品目录编号	330175
品牌系列	Calbiochem®
同义词	NSC-13502, Quinomycin A

参考
参考	Park, J.Y., et al. 2008. Cell. Biol. Int. 32, 1207. Kong, D., et al. 2005. Cancer Res. 65, 9047. Chang, A.Y., et al. 1998. Cancer 82, 292. Wadler, S., et al. 1994. Cancer Chemother. Pharmacol. 34, 266. Muss, H.B., et al. 1993. Am. J. Clin. Oncol. 16, 492. Foster, B.J., et al. 1985. Invest. New Drugs 3, 403. Van Dyke, N.M., et al. 1984. Science 225, 1122. Ward, D.C., et al. 1965. Science 149, 1259.

参考

Park, J.Y., et al. 2008. Cell. Biol. Int. 32, 1207.
Kong, D., et al. 2005. Cancer Res. 65, 9047.
Chang, A.Y., et al. 1998. Cancer 82, 292.
Wadler, S., et al. 1994. Cancer Chemother. Pharmacol. 34, 266.
Muss, H.B., et al. 1993. Am. J. Clin. Oncol. 16, 492.
Foster, B.J., et al. 1985. Invest. New Drugs 3, 403.
Van Dyke, N.M., et al. 1984. Science 225, 1122.
Ward, D.C., et al. 1965. Science 149, 1259.

产品信息
CAS号	512-64-1
形式	White solid
Hill配方	C₅₁H₆₄N₁₂O₁₂S₂
化学配方	C₅₁H₆₄N₁₂O₁₂S₂
Molar Mass	1101.3
结构配方图像

生物信息
纯度	≥98% by HPLC

理化信息
溶解度	DMSO

安全信息
R相	R: 23/24/25-46 Toxic by inhalation, in contact with skin and if swallowed. May cause heritable genetic damage.
S相	S: 36-36/37/39-45-53 Wear suitable protective clothing. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use.

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Toxic
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C.) Stock solutions are stable for up to 3 months at -20°C.