merck millipore,默克密理愽
  • merck millipore,默克密理博,07-509,Anti-phospho-PLCγ-1 (Tyr783) Antibody

  • merck millipore,默克密理博,07-509,Anti-phospho-PLCγ-1 (Tyr783) Antibody

    产品名称：Anti-phospho-PLCγ-1 (Tyr783) Antibody
    产品型号：07-509
    Detect phospho-PLCγ-1 (Tyr783) using this Anti-phospho-PLCγ-1 (Tyr783) Antibody validated for use in WB.

    merck millipore,默克密理博,07-509,Anti-phospho-PLCγ-1 (Tyr783) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-509,Anti-phospho-PLCγ-1 (Tyr783) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-509
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-PLCγ-1 (Tyr783) Antibody
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect phospho-PLCγ-1 (Tyr783) using this Anti-phospho-PLCγ-1 (Tyr783) Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Peptide corresponding to amino acids surrounding phospho-Tyr783 of human PLC gamma-1.
    宿主 Rabbit
    特异性 PLCγ-1 phosphorylated on Tyrosine 783.
    同种型 IgG
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002660
    Entrez基因汇总 The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • inositoltrisphosphohydrolase
    • PLCG1
    • PLC1
    • PLCgamma1
    • PLC148
    • PLC-II
    • PLC-148
    • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
    • PLC-gamma-1
    修改
    • Phosphorylation
    纯化方法 Protein A purfied
    UniProt编号
    • P19174
    UniProt汇总 FUNCTION: SwissProt: P19174 # PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
    COFACTOR: Calcium.
    SIZE: 1290 amino acids; 148532 Da
    SUBUNIT: Interacts with CENTG1 via its SH3 domain (By similarity). Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor- dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 (By similarity).
    PTM: The receptor-mediated activation of PLC-gamma-1 and PLC- gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors. & Ubiquitinated by CBLB in activated T-cells (By similarity).
    SIMILARITY: SwissProt: P19174 ## Contains 1 C2 domain. & Contains 1 EF-hand domain. & Contains 2 PH domains. & Contains 1 PI-PLC X-box domain. & Contains 1 PI-PLC Y-box domain. & Contains 2 SH2 domains. & Contains 1 SH3 domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot in RIPA lysates from EGFstimulated A431 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,07-509,Anti-phospho-PLCγ-1 (Tyr783) Antibody

上一件merck millipore产品：merck millipore,默克密理博,12-367,ATF2 (aa 19-96)
下一件merck millipore产品：merck millipore,默克密理博,03-34-0002,H-Arg-Gly-Asp-Ser-OH - CAS 91037-65-9 - Calbiochem


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