merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE144,Anti-Ago3 Antibody, clone 4B1-F6

  • merck millipore,默克密理博,MABE144,Anti-Ago3 Antibody, clone 4B1-F6

    产品名称：Anti-Ago3 Antibody, clone 4B1-F6
    产品型号：MABE144
    Anti-Ago3 Antibody, clone 4B1-F6 is a Mouse Monoclonal Antibody for detection of Ago3 also known as eIF-2C 3, eIF2C 3, FLJ12765, MGC86946 & has been validated in ICC & IP.

    merck millipore,默克密理博,MABE144,Anti-Ago3 Antibody, clone 4B1-F6

  • 产品介绍
  • merck millipore,默克密理博,MABE144,Anti-Ago3 Antibody, clone 4B1-F6

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE144
    描述 Anti-Ago3 Antibody, clone 4B1-F6
    Alternate Names
    • MGC86946
    • eIF-2C 3
    • eIF2C 3
    • FLJ12765
    背景信息 Eukaryotic translation initiation factor 2C 3, Ago3, belongs to the argonaute family and contains 1 PAZ and 1 Piwi domain.
    Ago3 is indicated to play a role in the RNA interference (RNAi) pathway, which is important for heterochromatin formation and accurate chromosome segregation. Unlike Ago1 and Ago2, Ago3 and AG04 do not possess the ability to dissociate miRNA duplexes in a minimal in vitro system. Re-introduction of any Ago variant into embyronic (ES) cells deficient for expression of all four Ago variants will rescue miRNA silencing defects and reduce apoptosis.
    产品信息
    格式 Purified
    控制
    • HeLa cells
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Ago3 Antibody, clone 4B1-F6 is a Mouse Monoclonal Antibody for detection of Ago3 also known as eIF-2C 3, eIF2C 3, FLJ12765, MGC86946 & has been validated in ICC & IP.
    主要应用
    • Immunocytochemistry
    应用说明 Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in HeLa cells. (Azuma-Mukai, A., et al. (2008). Proc Natl Acad Sci. USA. 105(23):7964-7969.)
    生物信息
    免疫原品种 Recombinant protein corresponding to human Ago3.
    克隆 4B1-F6
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody has been shown to not cross react with Ago1, Ago2, or Ago4 (Azuma-Mukai A et al. (2008) Proc. Natl. Acad. Sci. USA 105: 7964-7969).
    同种型 IgG2aκ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_079128
    Entrez基因汇总 This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
    基因符号
    • AGO3
    • EIF2C3
    纯化方法 Protein G purified
    UniProt编号
    • Q9H9G7
    UniProt汇总 FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

    SUBUNIT STRUCTURE: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B.

    SUBCELLULAR LOCATION: Cytoplasm > P-body.
    产品使用声明
    质量保证 Evaluated by Immunocytochemistry in HeLa cells.

    Immunocytochemistry Analysis: A 1:500 dilution of this antibody detected Ago3 in HeLa cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE144,Anti-Ago3 Antibody, clone 4B1-F6

上一件merck millipore产品：merck millipore,默克密理博,03-34-0002,H-Arg-Gly-Asp-Ser-OH - CAS 91037-65-9 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,ABN294,Anti-Annexin A3 Antibody


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