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品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, FC R Purified Monoclonal Antibody 描述 产品目录编号 MABT81 描述 Anti-JAM-C Antibody, clone H33 (azide free) Alternate Names - JAM-3
- Junctional adhesion molecule C
- JAM-C
- JAM-2
- Junctional adhesion molecule 3
背景信息 Junctional adhesion molecule C (JAM-C) is an adhesion molecule found at endothelial intracellular junctions that plays a role in leukocyte transendothelial migration and other inflammatory events. JAM-C seems to be important in the pathophysiology of pancreatitis and therefore could be a promising clinical target. JAM-C expression has been shown to be increased when T lymphocytes are activated. Research has shown that controlling JAM-C may also be a way of controlling pathological angiogenesis. 产品信息 格式 Purified 控制 - VEGF treated HUVEC cells
演示 Purified rat monoclonal IgG2aκ in PBS without 0.05% sodium azide (preservative free). 应用 应用 Anti-JAM-C Antibody, clone H33 (azide free) is an antibody against JAM-C for use in FC & IC. 主要应用 - Immunocytochemistry
- Flow Cytometry
应用说明 Inhibition of Activity Assay: A representative lot was used by an independent laboratory to inhibit microvessel outgrowth in an adapted mouse aortic ring assay (Lamagna, C., et al. (2005). Cancer Res. 65:5703-5710).
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC (Lamagna, C., et al. (2005). Cancer Res. 65:5703-5710).
Functional Blocking: Mice treated with a representative lot of this antibody showed a trend toward a reduced number of leukocytes in the tissue at every time point analyzed (Bradfield, P.F., et al. (2007). Blood, 110(7):2545-2555).
Functional Blocking: Mice treated with a representative lot of this antibody showed a trend toward reduced diabetes incidence and blood glucose over time (Christen, S., et al. PLoS ONE. 8(1):e54675)生物信息 免疫原品种 Full length recombinant protein corresponding to mouse JAM-C. 克隆 H33 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 同种型 IgG2aκ 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with Human.
Predicted to react with Mouse based immunogen design.抗体类型 Monoclonal Antibody Entrez基因编号 - NP_075766
基因符号 - Jam3
纯化方法 Protein G Purified UniProt编号 - Q9D8B7
UniProt汇总 FUNCTION: May participate in cell-cell adhesion distinct from tight junctions.
SUBUNIT STRUCTURE: Interacts with JAM2 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICTY: Endothelial cells.
SEQUENCE SIMILARITIES: Belongs to the immunoglobulin superfamily.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.产品使用声明 质量保证 Evaluated by Flow Cytometry in VEGF treated HUVEC cells.
Flow Cytometry Analysis: A 1:125 dilution of this antibody detected JAM-C in VEGF treated HUVEC cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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