merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1079,Anti-Calcium/Calmodulin Kinase II Antibody, clone EP1829Y, rabbit monoclonal

  • merck millipore,默克密理博,04-1079,Anti-Calcium/Calmodulin Kinase II Antibody, clone EP1829Y, rabbit monoclonal

    产品名称：Anti-Calcium/Calmodulin Kinase II Antibody, clone EP1829Y, rabbit monoclonal
    产品型号：04-1079
    This Anti-Calcium/Calmodulin Kinase II Antibody, clone EP1829Y, Rabbit is validated for use in WB, IH, IH(P), IP, FC for the detection of Calcium/Calmodulin Kinase II.

    merck millipore,默克密理博,04-1079,Anti-Calcium/Calmodulin Kinase II Antibody, clone EP1829Y, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-1079,Anti-Calcium/Calmodulin Kinase II Antibody, clone EP1829Y, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MFC, WB, IHCRbUnpurifiedMonoclonal Antibody
    描述
    产品目录编号 04-1079
    描述 Anti-Calcium/Calmodulin Kinase II Antibody, clone EP1829Y, rabbit monoclonal
    Alternate Names
    • calcium/calmodulin-dependent protein kinase kinase 2, beta
    • CAMKK beta protein
    • CaM-KK beta
    • CaM-kinase kinase beta
    • CaMKK beta
    • Calcium/calmodulin-dependent protein kinase kinase beta
    • calcium/calmodulin-dependent protein kinase beta
    • calcium/calmodulin-dependent protein kinase kinase 2 beta
    背景信息 The Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV, Phosphorylase Kinase, and MLCK. The CaM Kinases are inactive in the absence of stimuli; binding to Ca2+/Calmodulin induces conformational changes and activation. CaM Kinases have broad substrate specificity, with many cellular functions.
    产品信息
    格式 Unpurified
    控制
    • Mouse brain lysate
    演示 Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
    应用
    应用 This Anti-Calcium/Calmodulin Kinase II Antibody, clone EP1829Y, Rabbit is validated for use in WB, IH, IH(P), IP, FC for the detection of Calcium/Calmodulin Kinase II.
    主要应用
    • Flow Cytometry
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry Analysis: A 1:100-250 dilution from a previous lot detected Calcium/Calmodulin Kinase II in human brain carcinoma tissue.
    Immunocytochemistry Analysis: A 1:250-500 dilution from a previous lot was used in IC.
    Flow Cytometry: A 1:80 dilution of a previous lot was used in flow cytometry.
    Immunoprecipitation Analysis: A 1:50 dilution from a previous lot was used in IP.
    Immunohistochemistry (Paraffin) Analysis:
    Representative lot data.
    Immunohistochemical staining of paraffin-embedded human brain carcinoma using Anti-Calcium/Calmodulin Kinase II, clone EP1829Y.
    生物信息
    免疫原品种 Synthetic peptide corresponding to residues on human Calcium/Calmodulin Kinase II.
    克隆 EP1829Y
    宿主 Rabbit
    特异性 This antibody recognizes Calcium/Calmodulin Kinase II.
    同种型 IgG
    品种反应性 RatHumanMouse
    Species Reactivity Note Human, mouse, and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_015981.2
    基因符号
    • MGC15254
    • CAMKK
    • CAMKKB
    • EC 2.7.11.17
    • KIAA0787
    纯化方法 Unpurified
    UniProt编号
    • Q96RR4
    UniProt汇总 FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal activation of CREB1 By similarity.
    CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
    ENZYME REGULATION: Activated by Ca2+/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca2+/calmodulin. In part, activity is independent on Ca2+/calmodulin By similarity.
    SUBUNIT STRUCTURE: Interacts with calmodulin By similarity.
    SUBCELLULAR LOCATION:Cytoplasm By similarity.
    TISSUE SPECIFICITY: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.
    DOMAIN: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates By similarity.
    PTM: Autophosphorylated By similarity.
    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot on Mouse brain lysates.
    Western Blot Analysis: A 1:20,000 dilution of this antibody was used to detect Calcium/Calmodulin Kinase II in mouse brain lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-1079,Anti-Calcium/Calmodulin Kinase II Antibody, clone EP1829Y, rabbit monoclonal

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