merck millipore,默克密理愽
  • merck millipore,默克密理博,07-2262,Anti-WNK3 Antibody

  • merck millipore,默克密理博,07-2262,Anti-WNK3 Antibody

    产品名称：Anti-WNK3 Antibody
    产品型号：07-2262
    This WNK3 antibody is validated for use in WB for the detection of the WNK3 protein.

    merck millipore,默克密理博,07-2262,Anti-WNK3 Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-2262,Anti-WNK3 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-2262
    描述 Anti-WNK3 Antibody
    Alternate Names
    • protein kinase, lysine deficient 3
    • WNK lysine deficient protein kinase 3
    • serine/threonine-protein kinase WNK3
    • Protein kinase with no lysine 3
    • Protein kinase lysine-deficient 3
    背景信息 WNK3 is a serine-threonine protein kinase and expressed throughout the nephron, but most commonly at intercellular junctions. In its active state, it is a promoter of NKCC2 and NCC activity. The opposite is true of WNK3 when in an inactive state. WNK3 changes the expression of these transporters in the membrane and is thought to be a regulator of blood pressure along with other members of the WNK family of protein kinases. In recent research, WNK3 has also been linked to regulating signaling cascades involved in tumorigenesis.
    产品信息
    格式 Affinity Purified
    控制
    • HEK293 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This WNK3 antibody is validated for use in WB for the detection of the WNK3 protein.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human WNK3.
    宿主 Rabbit
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse.
    Other homologies: Rat (74% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001002838
    Entrez基因汇总 This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
    基因符号
    • PRKWNK3
    • WNK3
    纯化方法 Affinity purified
    UniProt编号
    • Q9BYP7
    UniProt汇总 CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. UniProtKB Q9H4A3

    COFACTOR: Magnesium (By similarity). UniProtKB Q9H4A3

    ENZYME REGULATION: Activation requires autophosphorylation of Ser-308. Phosphorylation of Ser-304 also promotes increased activity By similarity. UniProtKB Q9JIH7

    TISSUE SPECIFICITY: Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen.

    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.

    Contains 1 protein kinase domain.

    CAUTION: Cys-176 is present instead of the conserved Lys which is expected to be an active site residue. Lys-159 appears to fulfill the required catalytic function. UniProtKB Q9JIH7
    产品使用声明
    质量保证 Evaluated by Western Blot in HEK293 cell lysate.

    Western Blot Analysis: 1:1,000 dilution of this antibody detected WNK3 on 10 µg of HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-2262,Anti-WNK3 Antibody

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