merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3830,Anti-Caveolin-1 Antibody, phospho-specific (Tyr14)

  • merck millipore,默克密理博,AB3830,Anti-Caveolin-1 Antibody, phospho-specific (Tyr14)

    产品名称：Anti-Caveolin-1 Antibody, phospho-specific (Tyr14)
    产品型号：AB3830
    This Anti-Caveolin-1 Antibody, phospho-specific (Tyr14) is validated for use in IP, WB for the detection of Caveolin-1.

    merck millipore,默克密理博,AB3830,Anti-Caveolin-1 Antibody, phospho-specific (Tyr14)

  • 产品介绍
  • merck millipore,默克密理博,AB3830,Anti-Caveolin-1 Antibody, phospho-specific (Tyr14)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, M, MkWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3830
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Caveolin-1 Antibody, phospho-specific (Tyr14)
    产品信息
    格式 Affinity Purified
    演示 Protein A and peptide affinity purified immunoglobulin. Liquid in 10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 100 μg/ml BSA, with 50% glycerol.
    应用
    应用 This Anti-Caveolin-1 Antibody, phospho-specific (Tyr14) is validated for use in IP, WB for the detection of Caveolin-1.
    主要应用
    • Western Blotting
    应用说明 Western blotting 1:1,000 (for best results, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight)

    Immunoprecipitation 1:50

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Tyr14 of human caveolin-1
    表位 phospho-specific (Tyr14)
    宿主 Rabbit
    特异性 Recognizes caveolin-1 only when phosphorylated at tyrosine 14. This antibody does not cross-react with caveolin-2, -3 or caveolin-1beta, or the short isoform of caveolin-1.
    品种反应性 RatHumanMouseMonkey
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001753.3
    Entrez基因汇总 The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
    基因符号
    • Caveolin-1.
    • CAV1
    • MSTP085
    • CAV
    • VIP21
    修改
    • Phosphorylation
    UniProt编号
    • Q03135
    UniProt汇总 FUNCTION: SwissProt: Q03135 # May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).
    SIZE: 178 amino acids; 20472 Da
    SUBUNIT: Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin.
    SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane, caveola; Peripheral membrane protein; Cytoplasmic side. Note=Membrane protein of caveolae. Potential hairpin-like structure in the membrane.
    TISSUE SPECIFICITY: In muscle and lung, less so in liver, brain and kidney.
    PTM: The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.
    SIMILARITY: SwissProt: Q03135 ## Belongs to the caveolin family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20ºC for 12 months, do not aliquot.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB3830,Anti-Caveolin-1 Antibody, phospho-specific (Tyr14)

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