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品种反应性 主要应用 宿主 格式 抗体类型 H WB R Purified Monoclonal Antibody 描述 产品目录编号 MABT187 描述 Anti-Kindlin-3 Antibody, clone 181A Alternate Names - Unc-112-related protein 2
- Fermitin family homolog 3
- Kindlin-3
- MIG2-like protein
背景信息 Kindlin-3 is an intracellular protein encoded by the FERMT3 gene and which binds directly to the β chain cytoplasmic tail of integrin in hematopoietic cells. This protein belongs to a family of adhesion plaque proteins, of which there are three members, which act to activate integrins. Kindlin-3 differs from Kindlins-1 and -2 in that its expression is restricted to hematopoietic systems and is especially high in spleen and megakaryocytes. It is a necessary component for integrin activation and for platelet aggregation. Mutations in FERMT3 and consequently to the encoding of Kindlin-3 protein are causal to LAD-I variant syndrome, an uncommon genetic disorder in which integrin adhesive functions on platelets and leukocytes are disrupted. 产品信息 格式 Purified 控制 - K562 cell lysate
演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Kindlin-3 Antibody, clone 181A is an antibody against Kindlin-3 for use in Western Blotting. 主要应用 - Western Blotting
生物信息 免疫原品种 His-tagged recombinant protein corresponding to human Kindlin-3. 克隆 181A 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_113659
基因符号 - URP2
- FERMT3
- KIND3
- MIG2B
纯化方法 Protein G purified UniProt编号 - Q86UX7
产品使用声明 质量保证 Evaluated by Western Blot in K562 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Kindlin-3 in 10 µg of K562 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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