merck millipore,默克密理博,529581,PP1 Analog II, 1NM-PP1 - CAS 221244-14-0

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Merck Millipore 默克密理愽

merck millipore,默克密理博,529581,PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem

经验配方	CAS号
C₂₀H₂₁N₅	221244-14-0

描述
概述	A cell-permeable and reversible PP1 analog (Cat. No. 529579) that acts as a potent and selective ATP-competitive inhibitor of mutant kinases over wild-type (IC₅₀ = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIα-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase. Also available as a 10 mM solution in DMSO (Cat. No. 529606).
产品目录编号	529581
品牌系列	Calbiochem®
同义词	Mutant Kinases Inhibitor II, 4-Amino-1-tert-butyl-3-(1ʹ-naphthylmethyl)pyrazolo[3,4-d]pyrimidine, NM

参考
参考	Ira, G., et al. 2004. Nature 431, 1011. Papa, F.R., et al. 2003. Science 302, 1533. Bishop, A.C., et al. 2000. Nature 407, 395. Weiss, E.L., et al. 2000. Nat. Cell Biol. 2, 677. Bishop, A.C., et al. 1999. J. Am. Chem. Soc. 121, 627.

生物信息
主靶	T339G
主靶IC₅₀	3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIα-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs.
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,529581,PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem

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