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经验配方 CAS号 C₈H₅F₃N₂OS 1744-22-5 描述 概述 A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Shown to function as a polyglutamine aggregation inhibitor and stimulates the synthesis of NGF, BDNF, and GDNF in mouse astrocyte cultures. Reported to offer neuroprotection, slow down disease progression in ALS (amyotrophic lateral sclerosis) patients, and prolong the lifespan of animal models of HD (Huntington’s disease). 产品目录编号 557324 品牌系列 Calbiochem®
同义词 2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124 参考 参考 Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 16400.
Schiefer, J., et al. 2002. Mov. Disord. 17, 748.
Mizuta, I., et al. 2001. Neurosci. Lett. 310, 117.
Louvel, E., et al. 1997. Trends Pharmacol. Sci. 18, 196.
Mizoule, J., et al. 1985. Neuropharmacology 24, 767.产品信息 CAS号 1744-22-5 具有ATP竞争性 N 形式 White to off-white solid Hill配方 C₈H₅F₃N₂OS 化学配方 C₈H₅F₃N₂OS Molar Mass 234.2 可逆 N 生物信息 主靶 Inhibits glutamate release and blocks Na+ channels 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 污染物 Heavy metals: ≤20 ppm 溶解度 DMSO or HCl GHS安全信息 RTECS DL2830000 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Toxic
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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