- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,MABF101,Anti-IL-8R (CXCR2) Antibody, clone RII115
产品名称：Anti-IL-8R (CXCR2) Antibody, clone RII115
产品型号：MABF101
Anti-IL-8R (CXCR2) Antibody, clone RII115 detects level of IL-8R (CXCR2) & has been published & validated for use in FC.
merck millipore,默克密理博,MABF101,Anti-IL-8R (CXCR2) Antibody, clone RII115
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M Purified Monoclonal Antibody 描述 产品目录编号 MABF101 描述 Anti-IL-8R (CXCR2) Antibody, clone RII115 Alternate Names - CD182
- C-X-C chemokine receptor type 2
- CXC-R2
- CXCR-2
- CDw128b
- GRO/MGSA receptor
- High affinity interleukin-8 receptor B
- IL-8R B
- IL-8 receptor type 2
背景信息 Interleukin 8 Receptor beta (IL-8R), also known as CXCR2, is a type of G-protein coupled receptor and binds to interleukin 8 with high affinity to tranduce the signal thorugh a G-protein activated secondary messenger system. Knockout studies shows IL-8R alleviates both replicative and oncogene-induced senescence and diminishes the DNA-damage response. Ectopic expression results in premature senescence through a p53-dependent mechanism. 产品信息 格式 Purified 控制 - Human neutrophils
演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-IL-8R (CXCR2) Antibody, clone RII115 detects level of IL-8R (CXCR2) & has been published & validated for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Linear peptide corresponding to human IL-8R. 克隆 RII115 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2bκ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001161770
Entrez基因汇总 The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]. 基因符号 - IL8RB
- CXCR2
纯化方法 Protein G Purified UniProt编号 - P25025
UniProt汇总 FUNCTION: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: Phosphorylated upon ligand binding; which is required for desensitization.
SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family.产品使用声明 质量保证 Evaluated by Flow Cytometry in human neutrophils.
Flow Cytometry Analysis: 0.5 µg of this antibody detected IL-8R in human neutrophils.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,FCMAB349F,Milli-Mark™ Anti-Dynein-FITC Antibody, clone 74.1
下一件merck millipore产品：merck millipore,默克密理博,07-544,Anti-phospho-nNOS/NOS I (Ser1417) Antibody
相关产品
merck millipore,默克密理博,AB15546,Anti-MAML1 Antibody
merck millipore,默克密理博,557324,Riluzole - CAS 1744-22-5 - Calbiochem
merck millipore,默克密理博,AG322,Clock, control peptide for AB5416P
merck millipore,默克密理博,ABC29,Anti-ATG4A Antibody
merck millipore,默克密理博,FCMAB349F,Milli-Mark™ Anti-Dynein-FITC Antibody, clone 74.1
merck millipore,默克密理博,07-544,Anti-phospho-nNOS/NOS I (Ser1417) Antibody
merck millipore,默克密理博,AB15040,Anti-Calcyon Antibody
merck millipore,默克密理博,05-930,Anti-Alpha4 Antibody, clone 5F6
merck millipore,默克密理博,MAB5422,Anti-Choline Acetyltransferase Antibody