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  • merck millipore,默克密理博,06-549,Anti-Myc Tag Antibody

  • merck millipore,默克密理博,06-549,Anti-Myc Tag Antibody

    产品名称：Anti-Myc Tag Antibody
    产品型号：06-549
    Anti-Myc Tag Antibody is an antibody against Myc Tag for use in IC & WB.

    merck millipore,默克密理博,06-549,Anti-Myc Tag Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-549,Anti-Myc Tag Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ICCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-549
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Myc Tag Antibody
    Alternate Names
    • v-myc myelocytomatosis viral oncogene homolog (avian)
    • Transcription factor p64
    • avian myelocytomatosis viral oncogene homolog
    • myc proto-oncogene protein
    • v-myc avian myelocytomatosis viral oncogene homolog
    背景信息 Epitope tags are useful for the labeling and detection of proteins using immunoblotting, immunoprecipitation and immunostaining techniques. Due to their small size, they are unlikely to affect the tagged protein's biochemical properties. The Myc epitope tag is widely used to detect expression of recombinant proteins in bacteria, yeast, insect and mammalian cell systems.
    产品信息
    格式 Purified
    控制
    • Positive control for human Myc: widespread expression including A431 cell lysate, ovarian cancer cell lysate, or breast carcinoma tissue. Myc fusion protein expressed in cells.
    演示 Purified rabbit in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl with 0.05% sodium azide. Frozen solution.
    应用
    应用 Anti-Myc Tag Antibody is an antibody against Myc Tag for use in IC & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunocytochemistry:
    This antibody is reported to detect Myc-tagged proteins in transfected cells.
    生物信息
    免疫原品种 Synthetic peptide corresponding to residues 409-420 of human Myc (MEQKLISEEDLN).
    表位 a.a. 409-420
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes and is specific for human Myc and recombinant proteins containing the Myc epitope tag.
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Human. Other species cross-reactivity not tested.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002467.3
    Entrez基因汇总 The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
    基因符号
    • c-Myc
    • MYC
    • C-MYC
    纯化方法 Protein A chromatography
    UniProt编号
    • P01106
    UniProt汇总 FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
    SIZE: 439 amino acids; 48804 Da
    SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Phosphorylated by PRKDC.
    DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
    SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.
    产品使用声明
    质量保证 Evaluated by Western Blot on Myc-PP2A A subunit transfected NIH/3T3 lysates.

    Western Blotting:
    1:500 dilution of this antibody detected myc-PP2A on 10 μg of Myc-PP2A A subunit transfected NIH/3T3 lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,06-549,Anti-Myc Tag Antibody

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