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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Monoclonal Antibody 描述 产品目录编号 04-383 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MKK6 NT Antibody, rabbit monoclonal Alternate Names - MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3
- MAPKK6
- MEK6
- MKK6
- PRKMK6
产品信息 格式 Purified 控制 - POSITIVE: HeLa cells.
演示 Rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol. 应用 应用 This Anti-MKK6 NT Antibody is validated for use in IP, WB for the detection of MKK6 NT. 主要应用 - Western Blotting
应用说明 Western Blot: 1:10,000.
Immunoprecipitation: 1:50. The use of protein G agarose is recommended.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to residues in the N-term of human MKK6. 表位 N-terminus 宿主 Rabbit 特异性 Recognizes MKK6. 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002758.3
Entrez基因汇总 This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. 基因符号 - MKK6
- MAP2K6
- MEK6
- PRKMK6
- SAPKK3
- MAPKK6
纯化方法 Protein G purfied UniProt编号 - P52564
UniProt汇总 FUNCTION: SwissProt: P52564 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively.
SIZE: 334 amino acids; 37492 Da
SUBUNIT: Interacts with Yersinia yopJ.
TISSUE SPECIFICITY: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas.
PTM: Weakly autophosphorylated. & Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
SIMILARITY: SwissProt: P52564 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by immunoblot analysis. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,EZMIL6,Mouse IL-6 ELISA Kit, EZMIL6
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