merck millipore,默克密理愽
  • merck millipore,默克密理博,364205,GM 6001 - CAS 142880-36-2 - Calbiochem

  • merck millipore,默克密理博,364205,GM 6001 - CAS 142880-36-2 - Calbiochem

    产品名称：GM 6001 - CAS 142880-36-2 - Calbiochem
    产品型号：364205
    A potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of MMPs.

    merck millipore,默克密理博,364205,GM 6001 - CAS 142880-36-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,364205,GM 6001 - CAS 142880-36-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₂₈N₄O₄142880-36-2
    描述
    概述 A potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs); (Ki = 400 pM for MMP-1; Ki = 500 pM for MMP-2; Ki = 27 nM for MMP-3; Ki = 100 pM for MMP-8; and Ki = 200 pM for MMP-9). Prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice. A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364206) in DMSO is also available.
    产品目录编号 364205
    品牌系列 Calbiochem®
    同义词 Galardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide
    参考
    参考 Solorzano, C.C., et al. 1997. Shock 7, 427.
    Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
    Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
    Galardy, R.E. 1993. Drugs Future 18, 1109.
    Grobelny, D., et al. 1992. Biochemistry 31, 7152.
    产品信息
    CAS号 142880-36-2
    具有ATP竞争性 N
    形式 Off-white solid
    Hill配方 C₂₀H₂₈N₄O₄
    化学配方 C₂₀H₂₈N₄O₄
    Molar Mass 388.5
    可逆 N
    结构配方图像
    生物信息
    主靶 MMP-1
    主靶Ki 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; 200 pM for MMP-9
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

    merck millipore,默克密理博,364205,GM 6001 - CAS 142880-36-2 - Calbiochem

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