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品种反应性 主要应用 宿主 格式 抗体类型 M IHC, FC R Purified Monoclonal Antibody 描述 产品目录编号 MABC24 描述 Anti-LAMP-2 Antibody, clone M3/84 Alternate Names - CD107b antigen
- lysosomal-associated membrane protein 2
- CD107 antigen-like family member B
背景信息 Lysosome-associated membrane protein 2 (LAMP-2) is a highly glycosolated protein belonging to the lysosome-associated membrane protein family. This group pf proteins composes a significant portion of the lysosomal membrane and are considered crucial mediators for cellular adhesion by interacting with carbohydrate receptors. LAMP-2 is a profuse and critical component of the lysosomal membrane as it has been implicated in playing a role in lysosomal biogenesis. It also appears to be involved in later stages of phagocytosis and autophagy, where it may act to protect the lysosomal membrane from being digested, assist in signal transduction, moderate levels of acidity within the lysosomal environment, and participate in adhesion. Mutations in LAMP-2 expression have been associated with lysosomal storage diseases or LSDs, along with Danon disease, an X-linked disorder characterized by skeletal myopathy, mental retardation, and hypertrophic cardiomyopathy. 产品信息 格式 Purified 控制 - NIH/3T3 cells
演示 Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-LAMP-2 Antibody, clone M3/84 is validated for use in FC, IP, IH, IF for the detection of LAMP-2. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP (Springer, T., et al. (1981). The Journal of Biological Chemistry. 256(8):3833-3839).
Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Springer, T., et al. (1983). Am J Pathol. 111(1):112-24).
Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Deng. Y., et al. (1998). Proc. Nati. Acad. Sci. USA. 85:3860-3864).生物信息 免疫原品种 Murine macrophage membranes 克隆 M3/84 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 同种型 IgG1κ 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001017959
基因符号 - LAMP-2
- CD107b
- LAMPB
- LGP110
纯化方法 Protein G Purified UniProt编号 - P17047
UniProt汇总 FUNCTION: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.
PTM: O- and N-glycosylated; some of the N-linked glycans are polylactosaminoglycans (By similarity).
SEQUENCE SIMILARITIES: Belongs to the LAMP family.产品使用声明 质量保证 Evaluated by Flow Cytometry in NIH/3T3 cells.
Flow Cytometry Analysis: 10 µg of this antibody detected LAMP-2 in NIH/3T3 cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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