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品种反应性 主要应用 宿主 格式 抗体类型 M FC R Purified Monoclonal Antibody 描述 产品目录编号 04-1475 描述 Anti-CD27 Antibody, clone RM27-3E5 Alternate Names - tumor necrosis factor receptor superfamily, member 7
- CD27 antigen
- CD27 molecule
- CD27L receptor
- T cell activation antigen CD27
- T cell antivation antigen S152
- T-cell activation antigen CD27
- Tumor necrosis factor receptor superfamily member 7
背景信息 CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 and CD30 are also members of the TNF receptor superfamily. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is a membrane bound receptor, but a soluble form of CD27 is also produced. Soluble CD27 is found in body fluids and can be used to monitor local and systemic immune activation. In addition, elevated serum concentrations of soluble CD27 are found in patients with B cell malignancies and soluble CD27 levels strongly correlate with tumor load. 产品信息 格式 Purified 控制 - BALB/c splenocytes
演示 Purified rat monoclonal IgGκ (mixed) in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-CD27 Antibody, clone RM27-3E5 is an antibody against CD27 for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Recombinant protein corresponding to the extracellular domain of mouse CD27. 表位 Extracellular Domain 克隆 RM27-3E5 宿主 Rat 特异性 This antibody recognizes the extracellular domain of CD27. 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001028298
基因符号 - Tp55
- CD27
- S152
- T14
- TNFRSF7
纯化方法 Protein G purfied UniProt编号 - P41272
UniProt汇总 FUNCTION: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
SUBUNIT STRUCTURE: Homodimer. Interacts with SIVA1 and TRAF2 By similarity.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: In thymus and spleen, but not in non-lymphoid tissues.
SEQUENCE SIMILARITIES: Contains 3 TNFR-Cys repeats.产品使用声明 质量保证 Evaluated by Flow Cytometry in BALB/c splenocytes.
Flow Cytometry Analysis: A 1:125 dilution of a biotinylated version of this antibody detected CD27 in BALB/c splenocytes.
THIS ANTIBODY IS NOT BIOTINYLATED.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 50 µL
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