merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN681,Anti-TrkA Antibody, clone 6B2

  • merck millipore,默克密理博,MABN681,Anti-TrkA Antibody, clone 6B2

    产品名称：Anti-TrkA Antibody, clone 6B2
    产品型号：MABN681
    Anti-TrkA Antibody, clone 6B2 is a highly specific mouse monoclonal antibody, that targets TrkA & has been tested in western blotting, IHC & ICC.

    merck millipore,默克密理博,MABN681,Anti-TrkA Antibody, clone 6B2

  • 产品介绍
  • merck millipore,默克密理博,MABN681,Anti-TrkA Antibody, clone 6B2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HICC, WB, IHCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MABN681
    描述 Anti-TrkA Antibody, clone 6B2
    Alternate Names
    • p140-TrkA
    • High affinity nerve growth factor receptor
    • Neurotrophic tyrosine kinase receptor type 1
    • TRK1-transforming tyrosine kinase protein
    • Tropomyosin-related kinase A
    • Tyrosine kinase receptor
    • Tyrosine kinase receptor A
    • Trk-A
    • gp140trk
    背景信息 TrkA, apparent molecular weight 140 kDa, is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.
    产品信息
    格式 Ascites
    控制
    • Human brain tissue lysate
    演示 Mouse monoclonal IgG2b ascitic fluid containing up to 0.1% sodium azide.
    应用
    应用 Anti-TrkA Antibody, clone 6B2 is a highly specific mouse monoclonal antibody, that targets TrkA & has been tested in western blotting, IHC & ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected TrkA in human brain and rat cerebellum tissues.

    Immunocytochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected TrkA in PC-12 cells.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Purified recombinant extracellular fragment of TrkA expressed in HEK293 cells.
    克隆 6B2
    宿主 Mouse
    同种型 IgG1
    品种反应性 RatHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002520
    基因符号
    • TRKA
    • NTRK1
    • MTC
    • TRK
    纯化方法 Unpurified
    UniProt编号
    • P04629
    产品使用声明
    质量保证 Evaluated by Western Blotting in human brain tissue lysate.

    Western Blotting Analysis: A 1:500 dilution of this antibody detected TrkA in 10 µg of human brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABN681,Anti-TrkA Antibody, clone 6B2

上一件merck millipore产品：merck millipore,默克密理博,04-1475,Anti-CD27 Antibody, clone RM27-3E5
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