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merck millipore,默克密理博,164640,Aminopurvalanol A - CAS 220792-57-4 - Calbiochem
产品名称：Aminopurvalanol A - CAS 220792-57-4 - Calbiochem
产品型号：164640
A cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties.
merck millipore,默克密理博,164640,Aminopurvalanol A - CAS 220792-57-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₉H₂₆ClN₇O 220792-57-4 描述 概述 A cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 = ~ 1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~ 100-fold greater selectivity over a panel of kinases tested (IC50 ≥ 2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs. 产品目录编号 164640 品牌系列 Calbiochem®
同义词 (2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97 参考 参考 Breton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
Knockaert, M., et al. 2002.Oncogene 21, 6413.
Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.产品信息 CAS号 220792-57-4 具有ATP竞争性 Y 声明 Sold under license of U.S. Patent 6,255,485 and 6,617,331. 形式 Pale yellow solid Hill配方 C₁₉H₂₆ClN₇O 化学配方 C₁₉H₂₆ClN₇O Molar Mass 403.9 可逆 Y 结构配方图像 生物信息 主靶 Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35 主靶IC50 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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