merck millipore,默克密理愽
  • merck millipore,默克密理博,322337,Dvl-PDZ Domain Inhibitor, Peptide Pen-N3

  • merck millipore,默克密理博,322337,Dvl-PDZ Domain Inhibitor, Peptide Pen-N3

    产品名称：Dvl-PDZ Domain Inhibitor, Peptide Pen-N3
    产品型号：322337
    The Dvl-PDZ Domain Inhibitor, Peptide Pen-N3 controls the biological activity of Dvl-PDZ. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

    merck millipore,默克密理博,322337,Dvl-PDZ Domain Inhibitor, Peptide Pen-N3

  • 产品介绍
  • merck millipore,默克密理博,322337,Dvl-PDZ Domain Inhibitor, Peptide Pen-N3

    重要规格表

    经验配方
    C₁₆₃H₂₅₆N₄₈O₃₇S
    描述
    概述 A 22-amino acid PDZ domain-binding carboxamide toward Dvl (dishevelled) family proteins is fused at the N-terminal with a 16-mer antennapedia homeodomain-derived cell-permeable acetamide to facilitate its use in cellular studies. Shown to selectively inhibit the upregulation of cellular β-catenin accumulation and transcription activity upon Wnt3a stimulation (IC50 = 11 µM) or Dvl1/2/3 overexpression in HEK293 cultures, but not the Wnt3a- or Dvl1/2/3-independent, constitutively active Wnt pathway signaling in the APC-mutant HCT-15 colon cancer cells. Unlike Box5, the PDZ-interacting sequence in Pen-N3, originally identified via a random phage display screening, is not derived from Wnt or other known cellular proteins.
    产品目录编号 322337
    品牌系列 Calbiochem®
    同义词 Ac-RQIKIWFQNRRMKWKK-GGGEIVLWSDIP-NH₂, Dishevelled PDZ Domain Inhibitor, Wnt Pathway Inhibitor III
    参考
    参考 Zhang, Y., et al. 2009. Nat. Chem. Biol. 5, 217.
    产品信息
    形式 Lyophilized white solid
    配方 Supplied as a trifluoroacetate salt
    Hill配方 C₁₆₃H₂₅₆N₄₈O₃₇S
    化学配方 C₁₆₃H₂₅₆N₄₈O₃₇S
    Molar Mass 3512.2
    吸湿 Hygroscopic
    肽序列 Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Gly-Gly-Gly-Glu-Ile-Val-Leu-Trp-Ser-Asp-Ile-Pro-NH₂
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    肽序列 Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Gly-Gly-Gly-Glu-Ile-Val-Leu-Trp-Ser-Asp-Ile-Pro-NH₂
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,322337,Dvl-PDZ Domain Inhibitor, Peptide Pen-N3

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