merck millipore,默克密理博,SF-162,FBXW7; Human, Cyanine 5, RNA Detection Probe,SmartFlare

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merck millipore,默克密理博,SF-162,FBXW7; Human, Cyanine 5, RNA Detection Probe,SmartFlare
产品名称：FBXW7; Human, Cyanine 5, RNA Detection Probe, SmartFlare
产品型号：SF-162
Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare FBXW7, Human, Cyanine 5, you can detect FBXW7 RNA levels within your cells.

merck millipore,默克密理博,SF-162,FBXW7; Human, Cyanine 5, RNA Detection Probe,SmartFlare

产品介绍

merck millipore,默克密理博,SF-162,FBXW7; Human, Cyanine 5, RNA Detection Probe,SmartFlare

重要规格表

Entrez Gene Number	Species Reactivity
NM_033632.3	H

描述
产品目录编号	SF-162
商名	SmartFlare
描述	FBXW7; Human, Cyanine 5, RNA Detection Probe \| SmartFlare
Alternate Names	FBW6 AGO CDC4
背景信息	With SmartFlare™ RNA Detection probes, you can detect RNA in LIVE CELLS with ease. With just an overnight incubation of FBXW7; Human, Cyanine 5, RNA Detection Probe you can detect the presence of FBXW7 within your cells. The F-box protein family is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins are divided into 3 classes: FBWs containing WD-40 domains, FBLs containing leucine-rich repeats, and FBXs containing either different protein-protein interaction modules or no recognizable motifs. They constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. Cdc4 is one member of this family, which is also known as AGO, FBW7, FBX30 or SEL10. CDC4 binds directly to cyclin E and targets cyclin E for ubiquitin-mediated degradation. Cdc4 proteins of amino acid lengths varying from 553 aa to 707 aa in length have been reported. Cdc4 is an inhibitor of Notch signaling that targets Notch for ubiquitin-mediated degradation after a nuclear phosphorylation event.5,6 Cdc4 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. Thus, it may be important for Alzheimer's disease. Mutations of the CDC4 gene are detected in ovarian and breast cancer cell lines and the CDC4 gene may also be involved in the pathogenesis of human pancreatic and endometrial cancers.

产品信息
格式	Cyanine 5
演示	Lyophilized

应用
应用	Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare FBXW7, Human, Cyanine 5, you can detect FBXW7 RNA levels within your cells.
主要应用	RNA Detection

生物信息
品种反应性	Human
Entrez基因编号	NM_033632.3
基因符号	FBXW7

产品使用声明
质量保证	SmartFlare Probes have been tested in a buffer system to detect the release of the fluorophore in the presence of a complimentary base pair sequence for each lot to confirm target specificity. SmartFlare Probes have also been tested in a cell model system and demonstrated increased fluorescence in cells expressing the target compared to a negative SmartFlare Scramble Control.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Store at 2–8°C in lyophilized format ONLY. Room temperature is required for reconstituted product.

包装信息
数量	250 reactions

merck millipore,默克密理博,SF-162,FBXW7; Human, Cyanine 5, RNA Detection Probe,SmartFlare

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