• merck millipore,默克密理博,236005,COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem
  • merck millipore,默克密理博,236005,COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem

    产品名称:COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem
    产品型号:236005
    The COX-1 Inhibitor, FR122047, also referenced under CAS 130717-51-0, controls the biological activity of COX-1. This small molecule/inhibitor is primarily used for Cell Signaling applications.

    merck millipore,默克密理博,236005,COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,236005,COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₂₅N₃O₃S • HCl130717-51-0
    描述
    概述 A cell-permeable trisubstituted thiazole compound that acts as a potent and selective inhibitor of COX-1 (IC50 = 28 nM and 65 µM for human recombinant COX-1 and COX-2, respectively). Displays ~2,300 fold greater selectivity towards inhibition of COX-1 over COX-2. Reported to be orally active and display analgesic, anti-platelet and anti-inflammatory properties.
    产品目录编号 236005
    品牌系列 Calbiochem®
    同义词 FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride
    参考
    参考 Ochi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782.
    Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49.
    Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189.
    Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.
    产品信息
    CAS号 130717-51-0
    具有ATP竞争性 N
    形式 Pale yellow solid
    Hill配方 C₂₃H₂₅N₃O₃S • HCl
    化学配方 C₂₃H₂₅N₃O₃S • HCl
    Molar Mass 460.0
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 COX-1, COX-2
    主靶IC50 28 nM and 65 µM for human recombinant COX-1 and COX-2
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,236005,COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem

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