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merck millipore,默克密理博,236005,COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem
产品名称:COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem
产品型号:236005
The COX-1 Inhibitor, FR122047, also referenced under CAS 130717-51-0, controls the biological activity of COX-1. This small molecule/inhibitor is primarily used for Cell Signaling applications.
merck millipore,默克密理博,236005,COX-1 Inhibitor, FR122047 - CAS 130717-51-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₃H₂₅N₃O₃S • HCl 130717-51-0 描述 概述 A cell-permeable trisubstituted thiazole compound that acts as a potent and selective inhibitor of COX-1 (IC50 = 28 nM and 65 µM for human recombinant COX-1 and COX-2, respectively). Displays ~2,300 fold greater selectivity towards inhibition of COX-1 over COX-2. Reported to be orally active and display analgesic, anti-platelet and anti-inflammatory properties. 产品目录编号 236005 品牌系列 Calbiochem®
同义词 FR 122047, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride, 4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride 参考 参考 Ochi, T., and Goto, T. 2002. Br. J. Pharmacol. 135, 782.
Ochi, T., et al. 2000. Eur. J. Pharmacol. 391, 49.
Tanaka, A., et al. 1994. J. Med. Chem. 37, 1189.
Dohi, M., et al. 1993. Eur. J. Pharmacol. 243, 179.产品信息 CAS号 130717-51-0 具有ATP竞争性 N 形式 Pale yellow solid Hill配方 C₂₃H₂₅N₃O₃S • HCl 化学配方 C₂₃H₂₅N₃O₃S • HCl Molar Mass 460.0 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 COX-1, COX-2 主靶IC50 28 nM and 65 µM for human recombinant COX-1 and COX-2 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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