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描述 概述 Recombinant, human pro-MT5-MMP fused to a His•Tag® sequence, expressed in E. coli and activated to yield the active catalytic domain. Two isoforms are produced, one with an N-terminal Tyr156, the other with an N-terminal Leu158. Useful for the study of the activation of progelatinase A and the degradation of extracellular matrix proteins. MT5-MMP is a member of the Zn2+- and Ca2+-dependent endopeptidases that functions in the degradation of extracellular matrix components such as gelatin, chondroitin sulfate, and dermatan sulfate. It has a tendency to be shed from cell surface membranes and appears to undergo rapid autocatalytic destruction into smaller fragments. 产品目录编号 PF117 品牌系列 Calbiochem®
同义词 MMP-24, Catalytic Domain 参考 参考 Llano, E., et al. 1999. Cancer Res. 59, 2570.
Pei, D. 1999. J. Biol. Chem. 274, 8925.产品信息 形式 Liquid 配方 In 150 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl₂, pH 7.5. Molar Mass 22,000 防腐剂 None 生物信息 纯度 ≥95% by SDS-PAGE 特异活性 ≥100 mU/mg protein 浓缩标签 Please refer to vial label for lot-specific concentration
储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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