merck millipore,默克密理博,344281,Forskolin, NKH477 - CAS 138605-00-2

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merck millipore,默克密理博,344281,Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem
产品名称：Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem
产品型号：344281
A cell-permeable and water-soluble Forskolin derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskol More>>

merck millipore,默克密理博,344281,Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem

产品介绍

merck millipore,默克密理博,344281,Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem

重要规格表

经验配方	CAS号
C₂₇H₄₃NO₈ • HCl	138605-00-2

描述
概述	A cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.
产品目录编号	344281
品牌系列	Calbiochem®
同义词	6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl

参考
参考	Nakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462. Morinobu, S., et al. 1999. J. Neurochem. 72, 2198. Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753. Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97. Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339. Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625. Shafiq, J., et al. 1992. Circ. Res. 71, 70. Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.

参考

Nakashima, S., et al. 2005. J. Heart Lung Transplant. 24, 462.
Morinobu, S., et al. 1999. J. Neurochem. 72, 2198.
Satake, K., et al. 1998. Br. J. Pharmacol. 123, 753.
Toya, Y., et al. 1998. J. Mol. Cell Cardiol. 30, 97.
Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev. 13, 339.
Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19, 625.
Shafiq, J., et al. 1992. Circ. Res. 71, 70.
Hosono, M., et al. 1990. Eur. J. Pharmacol. 183, 2110.

产品信息
CAS号	138605-00-2
形式	White solid
Hill配方	C₂₇H₄₃NO₈ • HCl
化学配方	C₂₇H₄₃NO₈ • HCl
Molar Mass	546.1
吸湿	Hygroscopic
结构配方图像

生物信息
纯度	≥97% by HPLC

理化信息
溶解度	H₂O

安全信息
R相	R: 26/27/28-62-63 Very toxic by inhalation, in contact with skin and if swallowed. Possible risk of impaired fertility. Possible risk of harm to the unborn child.
S相	S: 22-24/25-36/37/39-45 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Highly Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	+2°C to +8°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.