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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN39 描述 Anti-Ceruloplasmin (CP) Antibody Alternate Names - Ferroxidase
- Ceruloplasmin
背景信息 Ceruloplasmin (CP), a member of the multicopper oxidase family, is a blue, copper-binding (6-7 atoms per molecule) glycoprotein that binds 90-95% of blood plasma and is involved in iron transport across the cell membrane. Ceruloplasmin plays an important role in antioxidant protection against organic and inorganic oxygen radicals generated by iron and ascorbate. Mutations in Ceruloplasmin have been associated with Wilson’s disease and aceruloplasminemia. 产品信息 格式 Affinity Purified 控制 - Human plasma lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Ceruloplasmin (CP) using this Anti-Ceruloplasmin (CP) Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: 0.1 µg/mL from a representative lot detected Ceruloplasmin on 10 µg of HepG2 cell lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Ceruloplasmin at the F5/8 type A 3 and Plastocyanin-like 5 domains. 表位 F5/8 type A 3 and Plastocyanin-like 5 domains 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Ceruloplasmin at the F5/8 type A 3 and Plastocyanin-like 5 domains. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human and Rat. Other homologies: Mouse (85% sequence homology). Rat (77% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000087
Entrez基因汇总 The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. [provided by RefSeq, Jul 2008]. 基因符号 - CP
纯化方法 Affinity purified UniProt编号 - P00450
UniProt汇总 FUNCTION: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
CATALYTIC ACTIVITY: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
COFACTOR: Binds 6 copper ions per monomer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
INVOLVEMENT IN DISEASE: Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
SEQUENCE SIMILARITIES: Belongs to the multicopper oxidase family.
Contains 3 F5/8 type A domains.
Contains 6 plastocyanin-like domains.产品使用声明 质量保证 Evaluated by Western Blot in human plasma lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected Ceruloplasmin on 10 µg of human plasma lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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