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  • merck millipore,默克密理博,ABN374,Anti-phospho-PTEN Antibody (Thr366)

  • merck millipore,默克密理博,ABN374,Anti-phospho-PTEN Antibody (Thr366)

    产品名称：Anti-phospho-PTEN Antibody (Thr366)
    产品型号：ABN374
    This Anti-phospho-PTEN Antibody (Thr366) is validated for use in western blotting & peptide inhibition assay for the detection of phospho-PTEN (Thr366).

    merck millipore,默克密理博,ABN374,Anti-phospho-PTEN Antibody (Thr366)

  • 产品介绍
  • merck millipore,默克密理博,ABN374,Anti-phospho-PTEN Antibody (Thr366)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABN374
    描述 Anti-phospho-PTEN Antibody (Thr366)
    Alternate Names
    • Phosphatase and tensin homolog
    • Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    • Mutated in multiple advanced cancers 1
    背景信息 The protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, in conjunction with FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation, creating PI(3,4,5)P3. In cells lacking PTEN, there are elevated levels of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration.
    产品信息
    格式 Affinity Purified
    控制
    • Peptide Inhibition Assay: 1.0 µg/mL of this antibody detected phospho-PTEN (Thr366) in 10 µg of lysate from cells transfected with PTEN mutant(C124S).
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-phospho-PTEN Antibody (Thr366) is validated for use in western blotting & peptide inhibition assay for the detection of phospho-PTEN (Thr366).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human phospho-PTEN (Thr366) near the C-terminus.
    表位 Near C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 Human
    Species Reactivity Note Human. Predicted to react with Mouse, Rat, Canine, Porcine, Zebrafish based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_000305
    基因符号
    • TEP1
    • PTEN
    • MMAC1
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • P60484
    产品使用声明
    质量保证 Evaluated by Western Blotting in lysate from cells transfected with PTEN mutant(C124S).

    Western Blotting Analysis: 1.0 µg/mL of this antibody detected phospho-PTEN (Thr366) in 10 µg of lysate from cells transfected with PTEN mutant(C124S).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,ABN374,Anti-phospho-PTEN Antibody (Thr366)

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