merck millipore,默克密理愽
  • merck millipore,默克密理博,MABT93,Anti-Abl interactor 1 Antibody, clone 19C3.1

  • merck millipore,默克密理博,MABT93,Anti-Abl interactor 1 Antibody, clone 19C3.1

    产品名称：Anti-Abl interactor 1 Antibody, clone 19C3.1
    产品型号：MABT93
    Detect Abl interactor 1 using this Anti-Abl interactor 1 Antibody, clone 19C3.1 validated for use in Western Blotting & IHC.

    merck millipore,默克密理博,MABT93,Anti-Abl interactor 1 Antibody, clone 19C3.1

  • 产品介绍
  • merck millipore,默克密理博,MABT93,Anti-Abl interactor 1 Antibody, clone 19C3.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, RIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT93
    描述 Anti-Abl interactor 1 Antibody, clone 19C3.1
    Alternate Names
    • e3B1
    • Abl interactor 1
    • Abelson interactor 1
    • Abi-1
    • Abl-binding protein 4
    • AblBP4
    • Eps8 SH3 domain-binding protein
    • Eps8-binding protein
    • Nap1-binding protein
    • Nap1BP
    • Spectrin SH3 domain-binding protein 1
    背景信息 Abl interactor 1 (Abelson interactor 1) is a member of the family of Abl-interactors and is highly expressed in the brain. Abl interactor 1 is involved in the signaling of ABL1 and ABL2 nonreceptor tyrosine kinases, and the EGF-receptor. The Abl interactor 1 protein contains SH3 domains, and may function as an adaptor protein; It forms a trimeric complex with EPS8 and SOS1 in the transduction of signals from Ras to Rac. Previous studies have suggested that Abl interactor 1 via the Ras and Rac pathways may regulate cell proliferation, cell adhesion, and actin remodeling. Abl interactor 1 is also investigated for its role in tumor suppression.
    产品信息
    格式 Purified
    控制
    • Rat brain tissue lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4) and 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Abl interactor 1 using this Anti-Abl interactor 1 Antibody, clone 19C3.1 validated for use in Western Blotting & IHC.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Abl interactor 1 in rat hippocampus and rat cerebellum tissues. Endogenous Abl interactor 1 accumulates in the nucleus in an LMB dependent manner. (Asier Echarri, M., et al. (2004). Mol. Cell. Biol. 24(11):4979-4993.)
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human Abl interactor 1.
    克隆 19C3.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 HumanRat
    Species Reactivity Note Demonstrated to react with Rat and Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001012768
    Entrez基因汇总 This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011].
    基因符号
    • SSH3BP1
    • ABI1
    纯化方法 Protein G purified
    UniProt编号
    • Q8IZP0
    UniProt汇总 FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level (By similarity).

    SUBUNIT STRUCTURE: Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, and through its N-terminus with WASF1. Part of a complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of ABI1, EPS8 and SOS1 (By similarity). Interacts with SOS1, SOS2, GRB2, SPTA1 and the first SH3 domain of NCK1. Isoform 6 does not interact with NCK1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2.

    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Cell projection › lamellipodium (By similarity). Cell projection › filopodium (By similarity). Cell projection › growth cone (By similarity). Cell junction › synapse › synaptosome (By similarity). Cytoplasm › cytoskeleton (By similarity). Note: Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes (By similarity).

    TISSUE SPECIFICITY: Widely expressed, with highest expression in brain.

    DOMAIN: The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A (By similarity).

    PTM: In vitro substrate for v-Abl (By similarity). Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl.

    INVOLVEMENT IN DISEASE: Note=A chromosomal aberration involving ABI1 is a cause of acute leukemias. Translocation t(10;11)(p11.2;q23) with MLL. ABI1 isoform 2 was found to be present in acute leukemia MLL-ABI1 fusion transcript.

    SEQUENCE SIMILARITIES: Belongs to the ABI family.

    Contains 1 SH3 domain.

    Contains 1 t-SNARE coiled-coil homology domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in rat brain tissue lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected Abl interactor 1 on 10 µg of rat brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABT93,Anti-Abl interactor 1 Antibody, clone 19C3.1

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