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主要应用 品种 来源 纯度 CULT Human E.coli Greater than 98% by SDS-PAGE and HPLC analyses. . Endotoxin level is less than 0.1 ng per mg (1 EU/μg) of human TPO. 描述 产品目录编号 GF037 品牌系列 Chemicon®
商名 - Chemicon
描述 Thrombopoietin 概述 TPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. Chemicon's Human TPO is a soluble 18.5 kDa protein containing 174 amino acid residues which comprises the receptor binding domain of the Mpl-ligand protein. Alternate Names - TPO
产品信息 演示 Lyophilized protein from 5mM Tris, pH 7.6, with no additives. 应用 应用 TPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation & maturation of megakaryocytes & promotes increased circulating levels of platelets in vivo. 主要应用 - Cell Culture
生物信息 纯度 Greater than 98% by SDS-PAGE and HPLC analyses. . Endotoxin level is less than 0.1 ng per mg (1 EU/μg) of human TPO. 来源 E.coli 品种 Human 特异活性 The ED50 was determined by the dose-dependent stimulation of the proliferation of M07e cells is <=1.0 ng/mL, corresponding to a specific activity of >=1x10(e6) units/mg. Entrez基因编号 - NM_000460.2
- NM_199228.1
- NM_199356.1
Entrez基因汇总 Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. 基因符号 - MKCSF
- THPO
- TPO
- MGC163194
- MPLLG
- thrombopoietin
- MGDF
- ML
UniProt编号 - P40225
UniProt汇总 FUNCTION: SwissProt: P40225 # Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
SIZE: 353 amino acids; 37823 Da
SUBCELLULAR LOCATION: Secreted.
DOMAIN: SwissProt: P40225 Two-domain structure with an erythropoietin-like N- terminal and a Ser/Pro/Thr-rich C-terminal.
DISEASE: SwissProt: P40225 # Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
SIMILARITY: Belongs to the EPO/TPO family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The lyophilized powder, though stable at room temperature, is best stored at -20°C. Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.5-1.0 mg/mL. This solution can be diluted into other aqueous buffers and stored at 4ºC for 1 week or -20ºC for future use. Reconstituted TPO should be stored in working aliquots at -20°C. 包装信息 数量 10 µg
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下一件merck millipore产品：merck millipore,默克密理博,100110,AAPH - CAS 2997-92-4 - Calbiochem
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