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merck millipore,默克密理博,FCMAB387APC,Milli-Mark Anti-Integrin α3-APC Antibody, clone P1B5
产品名称：Milli-Mark Anti-Integrin α3-APC Antibody, clone P1B5
产品型号：FCMAB387APC
This Milli-Mark Anti-Integrin α3-APC Antibody, clone P1B5 is validated for use in Flow Cytometry for the detection of Milli-Mark Integrin α3-APC.
merck millipore,默克密理博,FCMAB387APC,Milli-Mark Anti-Integrin α3-APC Antibody, clone P1B5
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M APC Monoclonal Antibody 描述 产品目录编号 FCMAB387APC 商名 - Milli-Mark
描述 Milli-Mark® Anti-Integrin α3-APC Antibody, clone P1B5 Alternate Names - CD49c
背景信息 Integrins are a family of dimeric, transmembrane proteins that mediate cell-cell and extracellular matrix adhesion. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. The integrin family is composed of at least 15 alpha and 8 beta subunits that may form over twenty different alpha-beta non-covalently bound dimeric combinations on the cell surface. The alpha subunits all have some homology to each other, as do the beta subunits. Both of the subunits contribute to the binding of the ligand. Integrin alpha subunits contain seven weak sequence repeats in the N-terminal region, which may be important in ligand binding, and have been predicted to fold cooperatively into a single beta-propeller domain with seven beta-sheets. The alpha-3 subunit (CD49c) is highly concentrated in epithelial cells where it strongly adheres to Laminin-5 and Laminin-5 induced rapid adhesion can be blocked by antibodies against the alpha-3 integrin subunit. The alpha-3 subunit exists in two different splice variants, denoted as "A" and "B". The only difference that results from this differential splicing is a total change in the cytoplasmic domain, while the extracellular domain stays the same. Knock-out mice lacking this subunit show prenatal lethality and abnormalities in the kidneys. 产品信息 格式 APC 控制 - A431 cells
演示 Purified mouse monoclonal IgG1k conjugated to APC in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 This Milli-Mark Anti-Integrin α3-APC Antibody, clone P1B5 is validated for use in Flow Cytometry for the detection of Milli-Mark Integrin α3-APC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Human HT1080 cells. 表位 Cell-binding domain 克隆 P1B5 宿主 Mouse 同种型 IgG1 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002195
基因符号 - CD49C
- ITGA3
- GAP-B3
- CD49c
- FLJ34704
- MSK18
- VLA3a
- VL3A
- VCA-2
- FLJ34631
- FRP-2
- GAPB3
纯化方法 Protein A purified UniProt编号 - P26006
产品使用声明 质量保证 Evaluated by flow cytometry using A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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