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merck millipore,默克密理博,MAB379,Anti-Glutamate Receptor 5, 6, 7 Antibody, clone 4F5
产品名称：Anti-Glutamate Receptor 5, 6, 7 Antibody, clone 4F5
产品型号：MAB379
Anti-Glutamate Receptor 5, 6, 7 Antibody, clone 4F5 detects level of Glutamate Receptor 5 & has been published & validated for use in ELISA, IC, IH, RIA.
merck millipore,默克密理博,MAB379,Anti-Glutamate Receptor 5, 6, 7 Antibody, clone 4F5
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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, Mk IHC, ELISA, ICC M Ascites Monoclonal Antibody 描述 产品目录编号 MAB379 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Glutamate Receptor 5, 6, 7 Antibody, clone 4F5 Alternate Names - GluR5/6/7
产品信息 格式 Ascites 演示 Ascites. Liquid. Contains no preservative. 应用 应用 Anti-Glutamate Receptor 5, 6, 7 Antibody, clone 4F5 detects level of Glutamate Receptor 5 & has been published & validated for use in ELISA, IC, IH, RIA. 主要应用 - Immunohistochemistry
- ELISA
- Immunocytochemistry
应用说明 Immunohistochemistry on 4% paraformaldehyde fixed tissue:1:1,000-1:2,000 Immunocytochemistry
ELISA
RIA
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Recombinant fusion protein TrpE-GluR5 克隆 4F5 宿主 Mouse 特异性 Recognizes an epitope common to Glutamate Receptors 5, 6 and 7. No reactivity seen to GluR1, GluR2, GluR3 or GluR4. 同种型 IgM 品种反应性 RatHumanMonkey 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000830.3
Entrez基因汇总 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG>CGG; Q>R) within the second transmembrane domain, whiich is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. 基因符号 - EAA3
- GRIK1
- Glutamate receptor
- ionotropic kainate 1
- GluR-5
- GluR5
- Excitatory amino acid receptor 3
UniProt编号 - P22756
- P39086
- Q38PU4
UniProt汇总 FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). The unedited version (Q) assembles into a functional kainate-gated homomeric channel, whereas the edited version (R) is unable to produce channel activity when expressed alone. Both edited and unedited versions can form functional channels with GRIK4 and GRIK5 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,567706,Sphingomyelin, Bovine Spinal Cord - CAS 85187-10-6 - Calbiochem
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