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merck millipore,默克密理博,MABN633,Anti-a-Synuclein, clone 10D2 Antibody
产品名称：Anti-a-Synuclein, clone 10D2 Antibody
产品型号：MABN633
Anti-a-Synuclein, clone 10D2 Antibody is an antibody against a-Synuclein for use in western blotting, IHC & ELISA.
merck millipore,默克密理博,MABN633,Anti-a-Synuclein, clone 10D2 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ELISA, WB, IHC M Affinity Purified Monoclonal Antibody 描述 产品目录编号 MABN633 Replaces 04-1053 描述 Anti-a-Synuclein, clone 10D2 Antibody Alternate Names - NACP
- Non-A4 component of amyloid precursor
- Non-A beta component of AD amyloid
- Alpha-synuclein
背景信息 α-Synuclein, also known as Non-A beta component of AD amyloid or Non-A4 component of amyloid, or NACP, and encoded by the gene SNCA/NACP/PARK1, is a protein originally identified as non-Abeta component protein (NACP) in the amyloid enriched fraction isolated from Alzheimer’s brain tissue. α-Synuclein is expressed in neural tissue and non-neural tissues too. In neurons, α-Synuclein is localized to the nucleus, presynaptic termini and mitochondria of certain brain regions. α-Synuclein is a molecular chaperone that binds various proteins and compounds including synaptobrevin-2 protein and membrane phospholipids and is involved in vesicle trafficking and membrane transport within neurons. Natural, non-mutated α-Synuclein has autoproteolytic activity and naturally forms stable alpha helical tetramers. However, mutated α-Synuclein can aggregate to form insoluble pathological complexes such as Lewy Bodies inside neurons. Lewy Bodies also contain ubiquitin and it is thought that they are evidence of disrupted proteasome function with regards to α-synuclein but research is still continuing.
This antibody can be used as a sandwich ELISA pair with Cat. No. MABN389, Anti-Aggregated a-Synuclein, clone 5G4.产品信息 格式 Affinity Purified 演示 Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives. 应用 应用 Anti-a-Synuclein, clone 10D2 Antibody is an antibody against a-Synuclein for use in western blotting, IHC & ELISA. 主要应用 - ELISA
- Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry Analysis: A representative lot detected aggregated a-Synuclein in human brain tissues.
ELISA Analysis: A representative lot from an independent laboratory detected aggregated a-Synuclein in a sandwich ELISA with Cat. No. MABN389, Anti-Aggregated a-Synuclein, clone 5G4 (Kovacs, G. G., et al. (2012). Acta Neuropathol. 123(1):37-50.).生物信息 免疫原品种 Recombinant protein corresponding to human Synuclein. 克隆 10D2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000336
基因符号 - PARK1
- SNCA
- NACP
纯化方法 Affinity purified UniProt编号 - P37840
产品使用声明 质量保证 Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 1.5 µg/mL of this antibody detected a-Synuclein in 10 µg of human brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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