merck millipore,默克密理愽
  • merck millipore,默克密理博,IL032,Interleukin-12 Protein, Recombinant mouse

  • merck millipore,默克密理博,IL032,Interleukin-12 Protein, Recombinant mouse

    产品名称：Interleukin-12 Protein, Recombinant mouse
    产品型号：IL032
    The recombinant mouse Interleukin-12 protein (or IL-12 protein) is a regulatory protein produced by activated B lymphocytes & macrophages.

    merck millipore,默克密理博,IL032,Interleukin-12 Protein, Recombinant mouse

  • 产品介绍
  • merck millipore,默克密理博,IL032,Interleukin-12 Protein, Recombinant mouse

    重要规格表

    主要应用 品种 来源 纯度
    CULTMouseCHO cells (Chinese Hamster Ovarian cells)Greater than 95% by SDS-PAGE
    描述
    产品目录编号 IL032
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Interleukin-12 Protein, Recombinant mouse
    概述 Interleukin-12 (IL-12) is a regulatory protein produced by activated B lymphocytes and macrophages. The biological activities of IL-12 include the stimulation of growth of activated CD4+ and CD8+ T cells and NK cells. Mouse IL-12 is a disulfide linked heterodimeric protein with a molecular weight of 75 kDa comprised of disulfide-bonded 35 kDa (p35) and 40 kDa (p40) subunits.
    Alternate Names
    • IL-12
    产品信息
    演示 Sterile filtered then the protein was lyophilized from 0.5x PBS, pH 7.2
    应用
    应用 The recombinant mouse Interleukin-12 protein (or IL-12 protein) is a regulatory protein produced by activated B lymphocytes & macrophages.
    主要应用
    • Cell Culture
    应用说明 For most in vitro applications, IL-12 exerts its biological activity in the concentration range of 1.0 to 10.0 ng/mL.
    生物信息
    纯度 Greater than 95% by SDS-PAGE
    来源 CHO cells (Chinese Hamster Ovarian cells)
    品种 Mouse
    特异活性 Chemicon's mouse IL-12 is fully biologically active when compared to standards. The ED(50) as determined by the dose-dependent stimulation of IFN-gamma production by murine splenocytes co-stimulated with IL-12 is <= 0.1 ng/mL, corresponding to a specific activity of >= 1.0 x 10<sup>-7</sup> units/mg.
    Entrez基因汇总 This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
    UniProt编号
    • P43432
    • P29459
    • P29460
    • P43431
    UniProt汇总 FUNCTION: SwissProt: P29460 # Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
    SIZE: 328 amino acids; 37169 Da
    SUBUNIT: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide- linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
    SUBCELLULAR LOCATION: Secreted.
    PTM: Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.
    DISEASE: SwissProt: P29460 # Defects in IL12B are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
    SIMILARITY: SwissProt: P29460 ## Belongs to the type I cytokine receptor family. Type 3 subfamily. & Contains 1 fibronectin type-III domain. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The lyophilized IL-12, though stable at room temperature, is best stored at -20°C. Reconstitute in water to a concentration of 0.1-1.0mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use. Reconstituted IL-12 should be stored in undiluted aliquots at -20°C.
    包装信息
    数量 10 µg

    merck millipore,默克密理博,IL032,Interleukin-12 Protein, Recombinant mouse

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