merck millipore,默克密理博,648469,Troglitazone - CAS 97322-87-7

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merck millipore,默克密理博,648469,Troglitazone - CAS 97322-87-7 - Calbiochem
产品名称：Troglitazone - CAS 97322-87-7 - Calbiochem
产品型号：648469
A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ).

merck millipore,默克密理博,648469,Troglitazone - CAS 97322-87-7 - Calbiochem

产品介绍

merck millipore,默克密理博,648469,Troglitazone - CAS 97322-87-7 - Calbiochem

重要规格表

经验配方	CAS号
C₂₄H₂₇NO₅S	97322-87-7

描述
概述	A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMC) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21^Cip1 turnover by inhibiting PKC_δ signaling in VSMCs. Exerts positive inotropic effect via Ca²⁺ sensitization in the sarcoplasmic reticulum and inhibits Na⁺/H⁺ exchange activity and proliferation of macrovascular endothelial cells.
产品目录编号	648469
品牌系列	Calbiochem®

参考
参考	Masamune, A., et al. 2002. J. Biol. Chem. 277, 141. Boyault, S., et al. 2001. FEBS Lett. 501, 24. de Dios, S.T., et al. 2001. J. Diabetes Complications 15, 120. Furuse, Y., et al. 2001. Br. J. Pharmacol. 133, 1307. Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab. 86, 1306. Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol. 38, 909. Koga, H., et al. 2001. Hepatology 33, 1087. Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem. 276, 37731. Subbaramaiah, K., et al. 2001. J. Biol. Chem. 276, 12440. Takashima, T., et al. 2001. Int. J. Oncol. 19, 465. Takeda, K., et al. 2001. J. Biol. Chem. 276, 48950. Tanaka, T., et al. 2001. Cancer Res. 61, 2424. Wakino, S., et al. 2001. J. Biol. Chem. 276, 47650.

参考

Masamune, A., et al. 2002. J. Biol. Chem. 277, 141.
Boyault, S., et al. 2001. FEBS Lett. 501, 24.
de Dios, S.T., et al. 2001. J. Diabetes Complications 15, 120.
Furuse, Y., et al. 2001. Br. J. Pharmacol. 133, 1307.
Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab. 86, 1306.
Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol. 38, 909.
Koga, H., et al. 2001. Hepatology 33, 1087.
Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem. 276, 37731.
Subbaramaiah, K., et al. 2001. J. Biol. Chem. 276, 12440.
Takashima, T., et al. 2001. Int. J. Oncol. 19, 465.
Takeda, K., et al. 2001. J. Biol. Chem. 276, 48950.
Tanaka, T., et al. 2001. Cancer Res. 61, 2424.
Wakino, S., et al. 2001. J. Biol. Chem. 276, 47650.

产品信息
CAS号	97322-87-7
具有ATP竞争性	N
形式	Yellow solid
Hill配方	C₂₄H₂₇NO₅S
化学配方	C₂₄H₂₇NO₅S
Molar Mass	441.5
可逆	N
结构配方图像

生物信息
主靶	Peroxisome proliferator-activated receptors γ (PPARγ)
纯度	≥98% by TLC

理化信息
细胞可渗透	N
溶解度	DMSO or EtOH

GHS安全信息
RTECS	XJ5813130

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C.