merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL198,Anti-Cytokeratin 19 Antibody, clone BA 17

  • merck millipore,默克密理博,CBL198,Anti-Cytokeratin 19 Antibody, clone BA 17

    产品名称：Anti-Cytokeratin 19 Antibody, clone BA 17
    产品型号：CBL198
    Detect Cytokeratin 19 using this Anti-Cytokeratin 19 Antibody, clone BA 17 validated for use in WB, IC, IH(P).

    merck millipore,默克密理博,CBL198,Anti-Cytokeratin 19 Antibody, clone BA 17

  • 产品介绍
  • merck millipore,默克密理博,CBL198,Anti-Cytokeratin 19 Antibody, clone BA 17

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 CBL198
    Replaces CBL178
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cytokeratin 19 Antibody, clone BA 17
    产品信息
    格式 Purified
    演示 The monoclonal is presented at a concentration of 0.1mg/1ml in phosphate buffered saline containing 10mM sodium azide and 1% bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
    应用
    应用 Detect Cytokeratin 19 using this Anti-Cytokeratin 19 Antibody, clone BA 17 validated for use in WB, IC, IH(P).
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry

    Western blotting

    Suitable for staining frozen and paraffin wax embedded tissue sections after proteolytic enzyme digestion

    Cytokeratin 19 positive detection distinguishes malignant from benign breast tumours

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Human reduction mammoplasty organoids
    克隆 BA 17
    宿主 Mouse
    特异性 The antibody is specific to human cytokeratin 19 and is reactive with cells of epithelial origin. Cytokeratin 19 is the smallest human cytokeratin (40 kDa) and is found in many simple and invariably in some non-keratinising stratified squamous epithelia. All adenocarcinomas tested have been positive for cytokeratin 19.

    FUSION PARTNER: Px63 Ag 8.653 myeloma cell line
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002276.4
    Entrez基因汇总 The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.
    基因符号
    • CK-19
    • KRT19
    • Keratin-19
    • K19
    • CK19
    • MGC15366
    • K1CS
    • Cytokeratin-19
    UniProt编号
    • P08727
    UniProt汇总 FUNCTION: SwissProt: P08727 # Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
    SIZE: 400 amino acids; 44092 Da
    SUBUNIT: Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.
    TISSUE SPECIFICITY: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.DEVELOPMENTAL STAGE: Present in hair follicles at all stages of development.
    DOMAIN: SwissProt: P08727 This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
    SIMILARITY: Belongs to the intermediate filament family.
    MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,CBL198,Anti-Cytokeratin 19 Antibody, clone BA 17

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