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品种反应性 主要应用 宿主 格式 抗体类型 H FC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABT189 描述 Anti-Delta3 Antibody, clone 1E7.2 Alternate Names - Delta3
- Delta-like protein 3
- Drosophila Delta homolog 3
背景信息 DLL3, also known as Delta like ligand 3, is a transmembrane Delta-like protein principally found in the Golgi apparatus and endosomes where it promotes Notch family receptor degradation to inhibit primary neurogenesis. DLL3 is one of five DSL proteins that bind to the Notch receptor. Notch signaling pathways play key roles in cell-fate determination and differentiation in many tissues during embryonic and postnatal development. Notch ligands family members are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in the DLL3 gene causes autosomal recessive spondylocostal dysostosis. 产品信息 格式 Purified 控制 - Human liver tissue lysate
演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. 应用 应用 This Anti-Delta3 Antibody, clone 1E7.2 is validated for use in WB, FC for the detection of Delta3. 主要应用 - Flow Cytometry
- Western Blotting
应用说明 Flow Cytometry Analysis: 0.1 µg from a representative lot detected Delta3 in HEK293 cells. 生物信息 免疫原品种 Linear peptide corresponding to human Delta3. 克隆 1E7.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgMκ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_058637
Entrez基因汇总 This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. 基因符号 - DLL3
纯化方法 Purified by ion exchange chromatography UniProt编号 - Q9NYJ7
UniProt汇总 FUNCTION: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
SUBUNIT STRUCTURE: Can bind and activate Notch-1 or another Notch receptor (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Probable.
DOMAIN: The DSL domain is required for binding to the Notch receptor.
PTM: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation (By similarity).
INVOLVEMENT IN DISEASE: Defects in DLL3 are the cause of spondylocostal dysostosis type 1 (SCDO1) [MIM:277300]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
SEQUENCE SIMILARITIES: Contains 1 DSL domain.
Contains 6 EGF-like domains.产品使用声明 质量保证 Evaluated by Western Blot in human liver tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Delta3 on 10 µg of human liver tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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