merck millipore,默克密理博,MABT149,Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal

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merck millipore,默克密理博,MABT149,Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal
产品名称：Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal
产品型号：MABT149
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect CD11b/ITAM using this Anti-CD11b/ITAM Antibod More>>

merck millipore,默克密理博,MABT149,Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,MABT149,Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	FC, WB, ICC	Rb	Diluted Culture Supernatant	Monoclonal Antibody

描述
产品目录编号	MABT149
描述	Anti-CD11b/ITAM Antibody, clone EP1345Y, rabbit monoclonal
Alternate Names	CR-3 alpha chain CD11 antigen-like family member B integrin, alpha M (complement component receptor 3, alpha also known as CD11b<br />(p170), macrophage antigen alpha polypeptide) macrophage antigen alpha polypeptide neutrophil adherence receptor alpha-M subunit integrin alpha-M antigen CD11b (p170) CD11b antigen Neutrophil adherence receptor integrin, alpha M (complement component 3 receptor 3 subunit) Cell surface glycoprotein MAC-1 subunit alpha Leukocyte adhesion receptor MO1
背景信息	Integrin alpha-M (ITAM, ITGAM, CD11b, MAC-1 alpha subunit, CR3 alpha chain) is the alpha subunit of ITAM/beta-2 complex (CD11b/CD18, Mac-1), a leukocyte adhesion heterodimeric glycoprotein (1). ITAM belongs to integrin alpha chain family and it is predominately presented in human myeloid cells, NK1 cells, monocytes, and granulocytes. ITAM/beta-2 complex is a receptor for fibrinogen (binding to P1 and P1 peptides of gamma chain), factor X, and ICAM1. ITAM/beta-2 is implicated in adhesive interactions of monocytes, macrophages, and granulocytes. It is also linked to mediation of complement-coated particle uptake (2).

产品信息
格式	Diluted Culture Supernatant
控制	TF-1 cell lysate
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect CD11b/ITAM using this Anti-CD11b/ITAM Antibody, clone EP1345Y, Rabbit validated for use in WB, IC, IH(P), IP, FC.
主要应用	Flow Cytometry Western Blotting Immunocytochemistry
应用说明	Immunohistochemistry Analysis: 1:100-1:250 dilution from a representative lot detected CD11b/ITAM in human spleen tissue. Immunocytochemistry Analysis: 1:100-1:250 dilution from a representative lot was used in IC. Immunoprecipitation Analysis: 1:80 dilution from a representative lot was used in IP. Flow Cytometry Analysis: 1:20 dilution from a representative lot was used in FC.

生物信息
免疫原品种	Synthetic peptide corresponding to human CD11b/ITAM at the C-terminus.
表位	C-terminus
克隆	EP1345Y
宿主	Rabbit
同种型	IgG
品种反应性	Human
Species Reactivity Note	Demonstrated to react with human.
抗体类型	Monoclonal Antibody
Entrez基因编号	P11215
基因符号	MGC117044 CD11B CR3A MAC-1 MAC1A SLEB6 CD11b MO1A
纯化方法	Unpurified
UniProt编号	P11215
UniProt汇总	FUNCTION: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Predominantly expressed in monocytes and granulocytes. DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. INVOLVEMENT IN DISEASE: Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. SEQUENCE SIMILARITIES: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain.

产品使用声明
质量保证	Evaluated by Western Blot in TF-1 cell lysate. Western Blot Analysis: 1:2,000 dilution of this antibody detected CD11b/ITAM in TF-1 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.