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品种反应性 主要应用 宿主 格式 抗体类型 H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB10515 Replaces AB9902 描述 Anti-Cav1.2 alpha1c Antibody 背景信息 This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Many alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. 产品信息 格式 Affinity Purified 控制 - Western Blot : Mouse Pancreas lysate.
演示 Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. 应用 应用 Anti-Cav1.2 alpha1c Antibody is an antibody against Cav1.2 alpha1c for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminus region of human Cav1.2 alpha1c. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 The antibody reacts with the 170-240 kDa Cav1.2 alpha1c protein. 品种反应性 HumanMouse Species Reactivity Note Reacts with mouse. Other species have not been tested. 100% homology to human, 93.3% homology to (14/15aa) mouse, rat, opposum 抗体类型 Polyclonal Antibody Entrez基因编号 - Q13936
纯化方法 Antigen affinity purified UniProt编号 - Q01815
UniProt汇总 FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart.
SUBUNIT STRUCTURE: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CACNA2D4 By similarity.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: High expression in heart, followed by brain and spinal cord.
DOMAIN: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel By similarity.
PTM: Phosphorylation by PKA activates the channel By similarity.
SEQUENCE SIMILARITIES: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]
产品使用声明 质量保证 Western Blot Analysis: 1:1000 dilution of this antibody detected Cav1.2 alpha1c on mouse pancreas lysate. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at 2-8°C for 1 year from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,516355,Pentraxin 3/TSG-14, Mouse, Recombinant
下一件merck millipore产品：merck millipore,默克密理博,17-662,ChIPAb+ EZH2, clone AC22 - ChIP Validated Antibody and Primer Set
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