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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MABS196 Replaces 04-385 描述 Anti-mTOR/FRAP Antibody, clone 22C2 Alternate Names - Rapamycin target protein 1
- Serine/threonine-protein kinase mTOR
- FK506-binding protein 12-rapamycin complex-associated protein 1
- FKBP12-rapamycin complex-associated protein
- Mammalian target of rapamycin
- mTOR
- Mechanistic target of rapamycin
- Rapamycin and FKBP12 target 1
背景信息 The mammalian target of rapamycin (mTOR), also known as FRAP, RAFT, or RAPT, is a ubiquitously expressed serine/threonine kinase that belongs to the phosphoinositide 3-kinase–related kinase (PIKK) family. mTOR functions as a downstream effector in the PI3K pathway and is activated by the Akt kinase. mTOR responds to signals from growth factors and promotes protein synthesis underlying cell proliferation, by activation of the S6 kinase and inhibition of the 4E-BP protein involved in protein translation. Several studies have suggested that the proliferative functions of mTOR may contribute to the development of cancer. 产品信息 格式 Purified 控制 - Jurkat cell lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect the mTOR/FRAP protein using this Anti-mTOR/FRAP, clone 22C2 validated for use in WB & IP. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: A representative lot was used by an independent laboratory in neuroblastoma cells. (Hosoi, H., et al. (1998). Molecular Pharmacology. 54:815–824.)
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in Rho30 cell extracts. (Hosoi, H., et al. (1998). Molecular Pharmacology. 54:815–824.)生物信息 免疫原品种 Linear peptide corresponding to human mTOR/FRAP. 克隆 22C2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_004949
基因符号 - RAPT1
- MTOR
- FRAP
- FRAP1
- FRAP2
- RAFT1
纯化方法 Protein G purified UniProt编号 - P42345
产品使用声明 质量保证 Evaluated by Western Blot in Jurkat cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected mTOR/FRAP on 10 µg of Jurkat cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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