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merck millipore,默克密理博,526527,PIM Kinase Inhibitor VIII, R8-T198wt - Calbiochem
产品名称：PIM Kinase Inhibitor VIII, R8-T198wt - Calbiochem
产品型号：526527
The PIM Kinase Inhibitor VIII, R8-T198wt controls the biological activity of PIM Kinase. This small molecule/inhibitor is primarily used for Cancer applications.
merck millipore,默克密理博,526527,PIM Kinase Inhibitor VIII, R8-T198wt - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₁₁H₂₁₁N₅₉O₂₆S₁ 描述 概述 The human p27Kip1 C-terminus PIM-1 phosphorylation site- (Thr198) containing sequence is synthesized with an N-terminal Arg octamer/R8-containing sequence to facilitate its use as a cell-permeable, substrate-competitive PIM-1 inhibitor. Reported to completely prevents human prostate carcinoma DU145-derived tumor expansion for up to 17 days (0.5 µmol/animal on days 0 & 5; intratumoral injection) in mice in vivo when combined with a single Taxol (Cat. No. 580555) dosage on day zero (60 mg/kg; i.p.). Studies using FITC-conjugated R8-T198wt demonstrate that R8-T198wt-induced cell cycle arrest and apoptosis in PIM-1-expressing DU145 cells are direct consequences of inhibition of PIM-1-mediated p27Kip1 Thr198 and Bad Ser112 phosphorylation, respectively. 产品目录编号 526527 品牌系列 Calbiochem®
同义词 NH₂-GGGRRRRRRRRGC~KKPGLRRRQT-CO₂H, cpm-P27Kip1189-198 参考 参考 Morishita, D., et al. 2011. J. Biol. Chem. 286, 2681.
Morishita, D., et al. 2008. Cancer Res. 68, 5076.产品信息 形式 White solid 配方 Supplied as a trifluoroacetate salt Hill配方 C₁₁₁H₂₁₁N₅₉O₂₆S₁ 化学配方 C₁₁₁H₂₁₁N₅₉O₂₆S₁ Molar Mass 2820.4 吸湿 Hygroscopic
肽序列 H-Gly-Gly-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Cys-Lys-Lys-Pro-Gly-Leu-Arg-Arg-Arg-Gln-Thr-OH 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or H₂O 肽序列 H-Gly-Gly-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Cys-Lys-Lys-Pro-Gly-Leu-Arg-Arg-Arg-Gln-Thr-OH 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,670105,UDP-α-D-N-Acetylgalactosamine, Disodium Salt - CAS 108320-87-2 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,ABC91,Anti-HUNK Antibody
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