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merck millipore,默克密理博,MAB304,Anti-Acetylcholinesterase Antibody, clone AE-2
产品名称：Anti-Acetylcholinesterase Antibody, clone AE-2
产品型号：MAB304
Detect Acetylcholinesterase using this Anti-Acetylcholinesterase Antibody, clone AE-2 validated for use in IH, IP & WB.
merck millipore,默克密理博,MAB304,Anti-Acetylcholinesterase Antibody, clone AE-2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Mk, H, Mk WB, IHC M Ascites Monoclonal Antibody 描述 产品目录编号 MAB304 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Acetylcholinesterase Antibody, clone AE-2 产品信息 格式 Ascites 演示 Ascites. Liquid in 0.02M PBS, 0.25M NaCl, pH 7.2, with 0.1% sodium azide. 应用 应用 Detect Acetylcholinesterase using this Anti-Acetylcholinesterase Antibody, clone AE-2 validated for use in IH, IP & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry (unfixed):1:200-1:1000 does not react with fixed tissue; add antibody to perfused but unfixed tissue, then fix after primary incubation.
Western blot: 1:500-1:1,000 on SKBR-3 cells.
Immunoprecipitation: use 0.5% triton X-100 extracts and a rabbit antibody mouse capture antibody for best results.生物信息 免疫原品种 Acetylcholinesterase AChE from human erythrocyte. 克隆 AE-2 宿主 Mouse 特异性 Acetylcholinesterase from human and monkey. 同种型 IgG1 品种反应性 MonkeyHumanMonkey 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_015831.2
- NM_000665.3
Entrez基因汇总 Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. 基因符号 - EC 3.1.1.7
- ACHE
- N-ACHE
- acetylcholinesterase
- AChE
- YT
- ARACHE
UniProt编号 - P22303
UniProt汇总 FUNCTION: SwissProt: P22303 # Rapidly hydrolyzes choline released into the synapse.
SIZE: 614 amino acids; 67796 Da
SUBUNIT: Homotetramer; composed of disulfide-linked homodimers. Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity).
SUBCELLULAR LOCATION: Cell junction, synapse. Secreted (By similarity). Cell membrane; Peripheral membrane protein (By similarity). & Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side (By similarity).
SIMILARITY: SwissProt: P22303 ## Belongs to the type-B carboxylesterase/lipase family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months.. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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